4pis

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==Crystal structure of human adenovirus 8 protease in complex with a nitrile inhibitor==
==Crystal structure of human adenovirus 8 protease in complex with a nitrile inhibitor==
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<StructureSection load='4pis' size='340' side='right' caption='[[4pis]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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<StructureSection load='4pis' size='340' side='right'caption='[[4pis]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4pis]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PIS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PIS FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4pis]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_adenovirus_D8 Human adenovirus D8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PIS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4PIS FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3FU:N~2~-[(2R)-2-(3,5-DICHLOROPHENYL)-2-(DIMETHYLAMINO)ACETYL]-N-({2-[(Z)-IMINOMETHYL]PYRIMIDIN-4-YL}METHYL)-L-ISOLEUCINAMIDE'>3FU</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4pie|4pie]], [[4piq|4piq]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3FU:N~2~-[(2R)-2-(3,5-DICHLOROPHENYL)-2-(DIMETHYLAMINO)ACETYL]-N-({2-[(Z)-IMINOMETHYL]PYRIMIDIN-4-YL}METHYL)-L-ISOLEUCINAMIDE'>3FU</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pis FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pis OCA], [http://pdbe.org/4pis PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4pis RCSB], [http://www.ebi.ac.uk/pdbsum/4pis PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4pis ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4pis FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pis OCA], [https://pdbe.org/4pis PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4pis RCSB], [https://www.ebi.ac.uk/pdbsum/4pis PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4pis ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/B9A5C1_ADE08 B9A5C1_ADE08]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Altmann, E]]
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[[Category: Human adenovirus D8]]
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[[Category: Bernardi, A]]
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[[Category: Large Structures]]
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[[Category: Combrink, K]]
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[[Category: Altmann E]]
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[[Category: Ellis, D]]
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[[Category: Bernardi A]]
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[[Category: Erbel, P]]
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[[Category: Combrink K]]
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[[Category: Grosche, P]]
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[[Category: Ellis D]]
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[[Category: Hughes, N]]
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[[Category: Erbel P]]
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[[Category: Jarousse, N]]
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[[Category: Grosche P]]
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[[Category: Melkko, S]]
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[[Category: Hughes N]]
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[[Category: Ramage, P]]
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[[Category: Jarousse N]]
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[[Category: Sirockin, F]]
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[[Category: Mac Sweeney A]]
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[[Category: Sweeney, A Mac]]
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[[Category: Melkko S]]
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[[Category: Adenain]]
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[[Category: Ramage P]]
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[[Category: Cofactor]]
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[[Category: Sirockin F]]
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[[Category: Cysteine protease]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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[[Category: Nitrile inhibitor]]
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[[Category: Pvic]]
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Current revision

Crystal structure of human adenovirus 8 protease in complex with a nitrile inhibitor

PDB ID 4pis

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