3wg6
From Proteopedia
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==Crystal structure of conjugated polyketone reductase C1 from Candida parapsilosis complexed with NADPH== | ==Crystal structure of conjugated polyketone reductase C1 from Candida parapsilosis complexed with NADPH== | ||
| - | <StructureSection load='3wg6' size='340' side='right' caption='[[3wg6]], [[Resolution|resolution]] 2.20Å' scene=''> | + | <StructureSection load='3wg6' size='340' side='right'caption='[[3wg6]], [[Resolution|resolution]] 2.20Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3wg6]] is a 4 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[3wg6]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Candida_parapsilosis Candida parapsilosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WG6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3WG6 FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2Å</td></tr> |
| - | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3wg6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wg6 OCA], [https://pdbe.org/3wg6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3wg6 RCSB], [https://www.ebi.ac.uk/pdbsum/3wg6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3wg6 ProSAT]</span></td></tr> |
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/CPRC1_CANPA CPRC1_CANPA] NADPH-dependent conjugated polyketone reductase with broad substrate specificity and strict stereospecificity. Reduces ketopantoyl lactone (2-dehydropantolactone) and isatin. Does not act on menadione, p-nitrobenzaldehyde and pyridine-3-aldehyde.<ref>PMID:11826979</ref> <ref>PMID:14593510</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Candida parapsilosis]] |
| - | [[Category: Kataoka | + | [[Category: Large Structures]] |
| - | [[Category: Maruoka | + | [[Category: Kataoka M]] |
| - | [[Category: Miyakawa | + | [[Category: Maruoka S]] |
| - | [[Category: Nagata | + | [[Category: Miyakawa T]] |
| - | [[Category: Ohtsuka | + | [[Category: Nagata K]] |
| - | [[Category: Qin | + | [[Category: Ohtsuka J]] |
| - | [[Category: Shimizu | + | [[Category: Qin H-M]] |
| - | [[Category: Tanokura | + | [[Category: Shimizu S]] |
| - | [[Category: Yamamura | + | [[Category: Tanokura M]] |
| - | + | [[Category: Yamamura A]] | |
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Current revision
Crystal structure of conjugated polyketone reductase C1 from Candida parapsilosis complexed with NADPH
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Categories: Candida parapsilosis | Large Structures | Kataoka M | Maruoka S | Miyakawa T | Nagata K | Ohtsuka J | Qin H-M | Shimizu S | Tanokura M | Yamamura A
