4egg

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==Computationally Designed Self-assembling tetrahedron protein, T310==
==Computationally Designed Self-assembling tetrahedron protein, T310==
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<StructureSection load='4egg' size='340' side='right' caption='[[4egg]], [[Resolution|resolution]] 2.21&Aring;' scene=''>
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<StructureSection load='4egg' size='340' side='right'caption='[[4egg]], [[Resolution|resolution]] 2.21&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4egg]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Staac Staac]. The September 2013 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Designed Protein Cages'' by David Goodsell is [http://dx.doi.org/10.2210/rcsb_pdb/mom_2013_9 10.2210/rcsb_pdb/mom_2013_9]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EGG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4EGG FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4egg]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus_COL Staphylococcus aureus subsp. aureus COL]. The September 2013 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Designed Protein Cages'' by David Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2013_9 10.2210/rcsb_pdb/mom_2013_9]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EGG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EGG FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.21&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4dcl|4dcl]], [[3v4e|3v4e]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SACOL2570 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=93062 STAAC])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4egg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4egg OCA], [https://pdbe.org/4egg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4egg RCSB], [https://www.ebi.ac.uk/pdbsum/4egg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4egg ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4egg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4egg OCA], [http://pdbe.org/4egg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4egg RCSB], [http://www.ebi.ac.uk/pdbsum/4egg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4egg ProSAT]</span></td></tr>
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</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/ATRF2_STAAC ATRF2_STAAC]
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We describe a general computational method for designing proteins that self-assemble to a desired symmetric architecture. Protein building blocks are docked together symmetrically to identify complementary packing arrangements, and low-energy protein-protein interfaces are then designed between the building blocks in order to drive self-assembly. We used trimeric protein building blocks to design a 24-subunit, 13-nm diameter complex with octahedral symmetry and a 12-subunit, 11-nm diameter complex with tetrahedral symmetry. The designed proteins assembled to the desired oligomeric states in solution, and the crystal structures of the complexes revealed that the resulting materials closely match the design models. The method can be used to design a wide variety of self-assembling protein nanomaterials.
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Computational design of self-assembling protein nanomaterials with atomic level accuracy.,King NP, Sheffler W, Sawaya MR, Vollmar BS, Sumida JP, Andre I, Gonen T, Yeates TO, Baker D Science. 2012 Jun 1;336(6085):1171-4. PMID:22654060<ref>PMID:22654060</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 4egg" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Designed Protein Cages]]
[[Category: Designed Protein Cages]]
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[[Category: Large Structures]]
[[Category: RCSB PDB Molecule of the Month]]
[[Category: RCSB PDB Molecule of the Month]]
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[[Category: Staac]]
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[[Category: Staphylococcus aureus subsp. aureus COL]]
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[[Category: Baker, D]]
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[[Category: Baker D]]
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[[Category: King, N P]]
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[[Category: King NP]]
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[[Category: Sawaya, M R]]
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[[Category: Sawaya MR]]
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[[Category: Sheffler, W]]
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[[Category: Sheffler W]]
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[[Category: Yeates, T O]]
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[[Category: Yeates TO]]
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[[Category: Self assembling tetrahedron design]]
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[[Category: Transferase]]
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Current revision

Computationally Designed Self-assembling tetrahedron protein, T310

PDB ID 4egg

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