4fuo

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==Structural basis for Zn2+-dependent intercellular adhesion in staphylococcal biofilms==
==Structural basis for Zn2+-dependent intercellular adhesion in staphylococcal biofilms==
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<StructureSection load='4fuo' size='340' side='right' caption='[[4fuo]], [[Resolution|resolution]] 1.97&Aring;' scene=''>
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<StructureSection load='4fuo' size='340' side='right'caption='[[4fuo]], [[Resolution|resolution]] 1.97&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4fuo]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Staeq Staeq]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FUO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4FUO FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4fuo]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_epidermidis_RP62A Staphylococcus epidermidis RP62A]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FUO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4FUO FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SCN:THIOCYANATE+ION'>SCN</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.97&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4fum|4fum]], [[4fun|4fun]], [[4fup|4fup]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SCN:THIOCYANATE+ION'>SCN</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">aap, SERP2398 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=176279 STAEQ])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4fuo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fuo OCA], [https://pdbe.org/4fuo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4fuo RCSB], [https://www.ebi.ac.uk/pdbsum/4fuo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4fuo ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4fuo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fuo OCA], [http://pdbe.org/4fuo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4fuo RCSB], [http://www.ebi.ac.uk/pdbsum/4fuo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4fuo ProSAT]</span></td></tr>
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</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/Q5HKE8_STAEQ Q5HKE8_STAEQ]
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SignificanceUnder adverse environmental conditions, bacteria can form specialized antibiotic-resistant colonies called "biofilms." In Staphylococcus epidermidis biofilms, a protein, Aap, links bacterial cells together but does so only in the presence of zinc ions. We have determined the atomic structure of an adhesive portion of Aap bound to zinc. The protein adopts an elongated, flexible fold with zinc ions bridging two protein chains. The mode of assembly indicates that Aap is likely to form twisted rope-like structures between bacterial cells. These data provide clues about regions of the protein that could be targeted to prevent intercellular adhesion in the developing biofilm.
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Structural basis for Zn2+-dependent intercellular adhesion in staphylococcal biofilms.,Conrady DG, Wilson JJ, Herr AB Proc Natl Acad Sci U S A. 2012 Dec 31. PMID:23277549<ref>PMID:23277549</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 4fuo" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Staeq]]
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[[Category: Large Structures]]
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[[Category: Conrady, D G]]
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[[Category: Staphylococcus epidermidis RP62A]]
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[[Category: Herr, A B]]
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[[Category: Conrady DG]]
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[[Category: Wilson, J J]]
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[[Category: Herr AB]]
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[[Category: Freestanding beta sheet]]
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[[Category: Wilson JJ]]
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[[Category: Hydrophilic protein]]
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[[Category: Intercellular adhesion]]
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[[Category: Membrane protein]]
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[[Category: Non-globular]]
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[[Category: Zinc dependent dimer]]
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Current revision

Structural basis for Zn2+-dependent intercellular adhesion in staphylococcal biofilms

PDB ID 4fuo

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