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4mrp

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==Structure of a bacterial Atm1-family ABC transporter==
==Structure of a bacterial Atm1-family ABC transporter==
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<StructureSection load='4mrp' size='340' side='right' caption='[[4mrp]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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<StructureSection load='4mrp' size='340' side='right'caption='[[4mrp]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4mrp]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Novad Novad]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MRP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4MRP FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4mrp]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Novosphingobium_aromaticivorans_DSM_12444 Novosphingobium aromaticivorans DSM 12444]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MRP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4MRP FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene>, <scene name='pdbligand=LDA:LAURYL+DIMETHYLAMINE-N-OXIDE'>LDA</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene>, <scene name='pdbligand=LDA:LAURYL+DIMETHYLAMINE-N-OXIDE'>LDA</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4mrp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mrp OCA], [https://pdbe.org/4mrp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4mrp RCSB], [https://www.ebi.ac.uk/pdbsum/4mrp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4mrp ProSAT]</span></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4mrn|4mrn]], [[4mrr|4mrr]], [[4mrs|4mrs]], [[4mrv|4mrv]]</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ATM1, Saro_2631 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=279238 NOVAD])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4mrp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mrp OCA], [http://pdbe.org/4mrp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4mrp RCSB], [http://www.ebi.ac.uk/pdbsum/4mrp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4mrp ProSAT]</span></td></tr>
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</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ATM1_NOVAD ATM1_NOVAD] Mediates the ATP-dependent export of glutathione-conjugated substrates, such as heavy metal-glutathione conjugates. ATP hydrolysis is stimulated by glutathione binding. Protects cells against toxic heavy metal ions, such as silver and mercury ions. May also mediate the transport of glutathione-conjugated aromatic hydrocarbons, such as dinitrobenzene.<ref>PMID:24604198</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Novad]]
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[[Category: Large Structures]]
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[[Category: Lee, J Y]]
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[[Category: Novosphingobium aromaticivorans DSM 12444]]
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[[Category: Lewinson, O]]
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[[Category: Lee JY]]
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[[Category: Rees, D C]]
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[[Category: Lewinson O]]
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[[Category: Yang, J G]]
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[[Category: Rees DC]]
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[[Category: Zhitnitsky, D]]
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[[Category: Yang JG]]
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[[Category: Heavy metal resistance]]
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[[Category: Zhitnitsky D]]
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[[Category: Membrane]]
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[[Category: Membrane protein]]
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[[Category: Substrate exporter]]
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[[Category: Transport protein]]
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Current revision

Structure of a bacterial Atm1-family ABC transporter

PDB ID 4mrp

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