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| | ==Crystallographic structure of FKBP12 from Aedes aegypti== | | ==Crystallographic structure of FKBP12 from Aedes aegypti== |
| - | <StructureSection load='3uqi' size='340' side='right' caption='[[3uqi]], [[Resolution|resolution]] 1.30Å' scene=''> | + | <StructureSection load='3uqi' size='340' side='right'caption='[[3uqi]], [[Resolution|resolution]] 1.30Å' scene=''> |
| | == Structural highlights == | | == Structural highlights == |
| - | <table><tr><td colspan='2'>[[3uqi]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Aedae Aedae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UQI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3UQI FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[3uqi]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Aedes_aegypti Aedes aegypti]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UQI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3UQI FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MPO:3[N-MORPHOLINO]PROPANE+SULFONIC+ACID'>MPO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.302Å</td></tr> |
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">AAEL007883, AaeL_AAEL007883 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7159 AEDAE])</td></tr> | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MPO:3[N-MORPHOLINO]PROPANE+SULFONIC+ACID'>MPO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> |
| - | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Peptidylprolyl_isomerase Peptidylprolyl isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.2.1.8 5.2.1.8] </span></td></tr>
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3uqi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3uqi OCA], [https://pdbe.org/3uqi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3uqi RCSB], [https://www.ebi.ac.uk/pdbsum/3uqi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3uqi ProSAT]</span></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3uqi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3uqi OCA], [http://pdbe.org/3uqi PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3uqi RCSB], [http://www.ebi.ac.uk/pdbsum/3uqi PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3uqi ProSAT]</span></td></tr> | + | |
| | </table> | | </table> |
| | + | == Function == |
| | + | [https://www.uniprot.org/uniprot/Q1HR83_AEDAE Q1HR83_AEDAE] |
| | <div style="background-color:#fffaf0;"> | | <div style="background-color:#fffaf0;"> |
| | == Publication Abstract from PubMed == | | == Publication Abstract from PubMed == |
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| | ==See Also== | | ==See Also== |
| - | *[[FK506 binding protein|FK506 binding protein]] | + | *[[FKBP 3D structures|FKBP 3D structures]] |
| | == References == | | == References == |
| | <references/> | | <references/> |
| | __TOC__ | | __TOC__ |
| | </StructureSection> | | </StructureSection> |
| - | [[Category: Aedae]] | + | [[Category: Aedes aegypti]] |
| - | [[Category: Peptidylprolyl isomerase]] | + | [[Category: Large Structures]] |
| - | [[Category: Saw, K Q]] | + | [[Category: Saw KQ]] |
| - | [[Category: Sreekanth, R]] | + | [[Category: Sreekanth R]] |
| - | [[Category: Yoon, H S]] | + | [[Category: Yoon HS]] |
| - | [[Category: Fk506 binding]]
| + | |
| - | [[Category: Fkbp12]]
| + | |
| - | [[Category: Isomerase]]
| + | |
| Structural highlights
Function
Q1HR83_AEDAE
Publication Abstract from PubMed
Dengue is one of the most infectious viral diseases prevalent mainly in tropical countries. The virus is transmitted by Aedes species of mosquito, primarily Aedes aegypti. Dengue remains a challenging drug target for years as the virus eludes the immune responses. Currently, no vaccines or antiviral drugs are available for dengue prevention. Previous studies suggested that the immunosuppressive drug FK506 shows antimalarial activity, and its molecular target, FK506-binding protein (FKBP), was identified in the Plasmodium parasite. Likewise, a FKBP family protein has been identified in A. aegypti (AaFKBP12) in which AaFKBP12 is assumed to play a similar role in its life cycle. FKBPs belong to a highly conserved class of proteins and are considered as an attractive pharmacological target. Herein, we present a high-resolution crystal structure of AaFKBP12 at 1.3 A resolution and discuss its structural features throwing light in facilitating the design of potential antagonists against the dengue-transmitting mosquito.
High-resolution crystal structure of FKBP12 from Aedes aegypti.,Rajan S, Saw KQ, Nguyen QT, Baek K, Yoon HS Protein Sci. 2012 Jul;21(7):1080-4. doi: 10.1002/pro.2079. Epub 2012 May 18. PMID:22517662[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
See Also
References
- ↑ Rajan S, Saw KQ, Nguyen QT, Baek K, Yoon HS. High-resolution crystal structure of FKBP12 from Aedes aegypti. Protein Sci. 2012 Jul;21(7):1080-4. doi: 10.1002/pro.2079. Epub 2012 May 18. PMID:22517662 doi:10.1002/pro.2079
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