4c7j

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (11:09, 9 May 2024) (edit) (undo)
 
(3 intermediate revisions not shown.)
Line 1: Line 1:
==11b-Hydroxysteroid Dehydrogenase Type I in complex with inhibitor==
==11b-Hydroxysteroid Dehydrogenase Type I in complex with inhibitor==
-
<StructureSection load='4c7j' size='340' side='right' caption='[[4c7j]], [[Resolution|resolution]] 2.16&Aring;' scene=''>
+
<StructureSection load='4c7j' size='340' side='right'caption='[[4c7j]], [[Resolution|resolution]] 2.16&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[4c7j]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C7J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4C7J FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[4c7j]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C7J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4C7J FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4YQ:4-CYCLOPROPYL-2-(2-HYDROXYETHYLOXY)-N-[(1S,3R)-5-OXIDANYL-2-ADAMANTYL]-1,3-THIAZOLE-5-CARBOXAMIDE'>4YQ</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.16&#8491;</td></tr>
-
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4c7k|4c7k]]</td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4YQ:4-CYCLOPROPYL-2-(2-HYDROXYETHYLOXY)-N-[(1S,3R)-5-OXIDANYL-2-ADAMANTYL]-1,3-THIAZOLE-5-CARBOXAMIDE'>4YQ</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
-
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/11-beta-hydroxysteroid_dehydrogenase 11-beta-hydroxysteroid dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.146 1.1.1.146] </span></td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4c7j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c7j OCA], [https://pdbe.org/4c7j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4c7j RCSB], [https://www.ebi.ac.uk/pdbsum/4c7j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4c7j ProSAT]</span></td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4c7j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c7j OCA], [http://pdbe.org/4c7j PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4c7j RCSB], [http://www.ebi.ac.uk/pdbsum/4c7j PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4c7j ProSAT]</span></td></tr>
+
</table>
</table>
== Disease ==
== Disease ==
-
[[http://www.uniprot.org/uniprot/DHI1_HUMAN DHI1_HUMAN]] Defects in HSD11B1 are a cause of cortisone reductase deficiency (CRD) [MIM:[http://omim.org/entry/604931 604931]]. In CRD, activation of cortisone to cortisol does not occur, resulting in adrenocorticotropin-mediated androgen excess and a phenotype resembling polycystic ovary syndrome (PCOS).
+
[https://www.uniprot.org/uniprot/DHI1_HUMAN DHI1_HUMAN] Defects in HSD11B1 are a cause of cortisone reductase deficiency (CRD) [MIM:[https://omim.org/entry/604931 604931]. In CRD, activation of cortisone to cortisol does not occur, resulting in adrenocorticotropin-mediated androgen excess and a phenotype resembling polycystic ovary syndrome (PCOS).
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/DHI1_HUMAN DHI1_HUMAN]] Catalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone. Catalyzes reversibly the conversion of 7-ketocholesterol to 7-beta-hydroxycholesterol. In intact cells, the reaction runs only in one direction, from 7-ketocholesterol to 7-beta-hydroxycholesterol (By similarity).
+
[https://www.uniprot.org/uniprot/DHI1_HUMAN DHI1_HUMAN] Catalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone. Catalyzes reversibly the conversion of 7-ketocholesterol to 7-beta-hydroxycholesterol. In intact cells, the reaction runs only in one direction, from 7-ketocholesterol to 7-beta-hydroxycholesterol (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 24: Line 23:
==See Also==
==See Also==
-
*[[Hydroxysteroid dehydrogenase|Hydroxysteroid dehydrogenase]]
+
*[[Hydroxysteroid dehydrogenase 3D structures|Hydroxysteroid dehydrogenase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: 11-beta-hydroxysteroid dehydrogenase]]
+
[[Category: Homo sapiens]]
-
[[Category: Boyd, S]]
+
[[Category: Large Structures]]
-
[[Category: Dossetter, A G]]
+
[[Category: Boyd S]]
-
[[Category: Goldberg, F W]]
+
[[Category: Dossetter AG]]
-
[[Category: Groombridge, S D]]
+
[[Category: Goldberg FW]]
-
[[Category: Gutierrez, P Morentin]]
+
[[Category: Groombridge SD]]
-
[[Category: Kemmitt, P D]]
+
[[Category: Kemmitt PD]]
-
[[Category: Robb, G R]]
+
[[Category: Morentin Gutierrez P]]
-
[[Category: Schoolmeester, J de]]
+
[[Category: Robb GR]]
-
[[Category: Scott, J S]]
+
[[Category: Scott JS]]
-
[[Category: Sjogren, T]]
+
[[Category: Sjogren T]]
-
[[Category: Swales, J G]]
+
[[Category: Swales JG]]
-
[[Category: Turnbull, A V]]
+
[[Category: Turnbull AV]]
-
[[Category: Wild, M J]]
+
[[Category: Wild MJ]]
-
[[Category: Cns penetration]]
+
[[Category: De Schoolmeester J]]
-
[[Category: Oxidoreductase]]
+
-
[[Category: Structure-based design]]
+

Current revision

11b-Hydroxysteroid Dehydrogenase Type I in complex with inhibitor

PDB ID 4c7j

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4c7j"
Personal tools