4pyp

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==Crystal structure of the human glucose transporter GLUT1==
==Crystal structure of the human glucose transporter GLUT1==
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<StructureSection load='4pyp' size='340' side='right' caption='[[4pyp]], [[Resolution|resolution]] 3.17&Aring;' scene=''>
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<StructureSection load='4pyp' size='340' side='right'caption='[[4pyp]], [[Resolution|resolution]] 3.17&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4pyp]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PYP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PYP FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4pyp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PYP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4PYP FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BNG:B-NONYLGLUCOSIDE'>BNG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.166&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pyp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pyp OCA], [http://pdbe.org/4pyp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4pyp RCSB], [http://www.ebi.ac.uk/pdbsum/4pyp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4pyp ProSAT]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BNG:B-NONYLGLUCOSIDE'>BNG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4pyp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pyp OCA], [https://pdbe.org/4pyp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4pyp RCSB], [https://www.ebi.ac.uk/pdbsum/4pyp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4pyp ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
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[[http://www.uniprot.org/uniprot/GTR1_HUMAN GTR1_HUMAN]] Hereditary cryohydrocytosis with reduced stomatin;Paroxysmal exertion-induced dyskinesia;Encephalopathy due to GLUT1 deficiency;Paroxysmal dystonic choreathetosis with episodic ataxia and spasticity;Childhood absence epilepsy;Epilepsy with myoclonic-astatic seizures. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.
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[https://www.uniprot.org/uniprot/GTR1_HUMAN GTR1_HUMAN] Hereditary cryohydrocytosis with reduced stomatin;Paroxysmal exertion-induced dyskinesia;Encephalopathy due to GLUT1 deficiency;Paroxysmal dystonic choreathetosis with episodic ataxia and spasticity;Childhood absence epilepsy;Epilepsy with myoclonic-astatic seizures. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/GTR1_HUMAN GTR1_HUMAN]] Facilitative glucose transporter. This isoform may be responsible for constitutive or basal glucose uptake. Has a very broad substrate specificity; can transport a wide range of aldoses including both pentoses and hexoses.
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[https://www.uniprot.org/uniprot/GTR1_HUMAN GTR1_HUMAN] Facilitative glucose transporter. This isoform may be responsible for constitutive or basal glucose uptake. Has a very broad substrate specificity; can transport a wide range of aldoses including both pentoses and hexoses.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 4pyp" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 4pyp" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[ABC transporter 3D structures|ABC transporter 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Deng, D]]
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[[Category: Homo sapiens]]
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[[Category: Hu, M X]]
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[[Category: Large Structures]]
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[[Category: Sun, P C]]
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[[Category: Deng D]]
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[[Category: Wu, J P]]
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[[Category: Hu MX]]
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[[Category: Xu, C]]
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[[Category: Sun PC]]
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[[Category: Yan, C Y]]
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[[Category: Wu JP]]
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[[Category: Yan, N]]
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[[Category: Xu C]]
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[[Category: Glycosylation]]
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[[Category: Yan CY]]
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[[Category: Helix]]
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[[Category: Yan N]]
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[[Category: Membrane transporter]]
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[[Category: Transport protein]]
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Current revision

Crystal structure of the human glucose transporter GLUT1

PDB ID 4pyp

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