4q3a

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==PylD cocrystallized with L-Lysine-Ne-3S-methyl-L-ornithine and NAD+==
==PylD cocrystallized with L-Lysine-Ne-3S-methyl-L-ornithine and NAD+==
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<StructureSection load='4q3a' size='340' side='right' caption='[[4q3a]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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<StructureSection load='4q3a' size='340' side='right'caption='[[4q3a]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4q3a]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Metbf Metbf]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Q3A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4Q3A FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4q3a]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Methanosarcina_barkeri_str._Fusaro Methanosarcina barkeri str. Fusaro]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Q3A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4Q3A FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2YC:N~6~-{[(2S,3S)-3-METHYL-3,4-DIHYDRO-2H-PYRROL-2-YL]CARBONYL}-L-LYSINE'>2YC</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAI:1,4-DIHYDRONICOTINAMIDE+ADENINE+DINUCLEOTIDE'>NAI</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3t7v|3t7v]], [[4ffp|4ffp]], [[4q39|4q39]], [[4q3e|4q3e]], [[4q3b|4q3b]], [[4q3c|4q3c]], [[4q3d|4q3d]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2YC:N~6~-{[(2S,3S)-3-METHYL-3,4-DIHYDRO-2H-PYRROL-2-YL]CARBONYL}-L-LYSINE'>2YC</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAI:1,4-DIHYDRONICOTINAMIDE+ADENINE+DINUCLEOTIDE'>NAI</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Mbar_A0835 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=269797 METBF])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4q3a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4q3a OCA], [https://pdbe.org/4q3a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4q3a RCSB], [https://www.ebi.ac.uk/pdbsum/4q3a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4q3a ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4q3a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4q3a OCA], [http://pdbe.org/4q3a PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4q3a RCSB], [http://www.ebi.ac.uk/pdbsum/4q3a PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4q3a ProSAT]</span></td></tr>
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</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PYLD_METBF PYLD_METBF] Catalyzes the ultimate step of the pyrrolysine biosynthesis pathway by converting the isopeptide (3R)-3-methyl-D-ornithyl-N(6)-L-lysine to the 22nd proteinogenic amino acid (PubMed:24916332). Is able to use surrogate substrates such as (3R)-D-ornithyl-N(6)-L-lysine in vitro (PubMed:23720358, PubMed:24916332).<ref>PMID:23720358</ref> <ref>PMID:24916332</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Metbf]]
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[[Category: Large Structures]]
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[[Category: Bacher, A]]
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[[Category: Methanosarcina barkeri str. Fusaro]]
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[[Category: Beck, P]]
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[[Category: Bacher A]]
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[[Category: Groll, M]]
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[[Category: Beck P]]
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[[Category: Quitterer, F]]
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[[Category: Groll M]]
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[[Category: Dehydrogenase]]
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[[Category: Quitterer F]]
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[[Category: Oxidoreductase]]
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[[Category: Pyrrolysine]]
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[[Category: Rossmann fold]]
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Current revision

PylD cocrystallized with L-Lysine-Ne-3S-methyl-L-ornithine and NAD+

PDB ID 4q3a

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