4cc6
From Proteopedia
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==Fragment-Based Discovery of 6 Azaindazoles As Inhibitors of Bacterial DNA Ligase== | ==Fragment-Based Discovery of 6 Azaindazoles As Inhibitors of Bacterial DNA Ligase== | ||
| - | <StructureSection load='4cc6' size='340' side='right' caption='[[4cc6]], [[Resolution|resolution]] 2.01Å' scene=''> | + | <StructureSection load='4cc6' size='340' side='right'caption='[[4cc6]], [[Resolution|resolution]] 2.01Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4cc6]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CC6 OCA]. For a <b>guided tour on the structure components</b> use [ | + | <table><tr><td colspan='2'>[[4cc6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CC6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4CC6 FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=L5Y:2-{[2-(1H-PYRAZOLO[3,4-C]PYRIDIN-3-YL)-6-(TRIFLUOROMETHYL)PYRIDIN-4-YL]AMINO}ETHANOL'>L5Y</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.01Å</td></tr> |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=L5Y:2-{[2-(1H-PYRAZOLO[3,4-C]PYRIDIN-3-YL)-6-(TRIFLUOROMETHYL)PYRIDIN-4-YL]AMINO}ETHANOL'>L5Y</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4cc6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cc6 OCA], [https://pdbe.org/4cc6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4cc6 RCSB], [https://www.ebi.ac.uk/pdbsum/4cc6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4cc6 ProSAT]</span></td></tr> | |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/DNLJ_STAAU DNLJ_STAAU] | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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</div> | </div> | ||
<div class="pdbe-citations 4cc6" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 4cc6" style="background-color:#fffaf0;"></div> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[DNA ligase 3D structures|DNA ligase 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: Amin | + | [[Category: Large Structures]] |
| - | [[Category: Benowitz | + | [[Category: Staphylococcus aureus]] |
| - | [[Category: Chiarparin | + | [[Category: Amin N]] |
| - | [[Category: Cui | + | [[Category: Benowitz AB]] |
| - | [[Category: Deng | + | [[Category: Chiarparin E]] |
| - | [[Category: Heightman | + | [[Category: Cui H]] |
| - | [[Category: Holmes | + | [[Category: Deng X]] |
| - | [[Category: Hopkins | + | [[Category: Heightman TD]] |
| - | [[Category: Howard | + | [[Category: Holmes DJ]] |
| - | [[Category: Huang | + | [[Category: Hopkins A]] |
| - | [[Category: Jin | + | [[Category: Howard S]] |
| - | [[Category: Kreatsoulas | + | [[Category: Huang J]] |
| - | [[Category: Martin | + | [[Category: Jin Q]] |
| - | [[Category: Massey | + | [[Category: Kreatsoulas C]] |
| - | [[Category: McCloskey | + | [[Category: Martin ACL]] |
| - | [[Category: Mortenson | + | [[Category: Massey F]] |
| - | [[Category: Pathuri | + | [[Category: McCloskey L]] |
| - | [[Category: Tisi | + | [[Category: Mortenson PN]] |
| - | [[Category: Williams | + | [[Category: Pathuri P]] |
| - | + | [[Category: Tisi D]] | |
| - | + | [[Category: Williams PA]] | |
| - | + | ||
Current revision
Fragment-Based Discovery of 6 Azaindazoles As Inhibitors of Bacterial DNA Ligase
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Categories: Large Structures | Staphylococcus aureus | Amin N | Benowitz AB | Chiarparin E | Cui H | Deng X | Heightman TD | Holmes DJ | Hopkins A | Howard S | Huang J | Jin Q | Kreatsoulas C | Martin ACL | Massey F | McCloskey L | Mortenson PN | Pathuri P | Tisi D | Williams PA
