4fc8

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==Crystal structure of transcription regulator protein Rtr1 from Kluyveromyces lactis==
==Crystal structure of transcription regulator protein Rtr1 from Kluyveromyces lactis==
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<StructureSection load='4fc8' size='340' side='right' caption='[[4fc8]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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<StructureSection load='4fc8' size='340' side='right'caption='[[4fc8]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4fc8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Candida_sphaerica Candida sphaerica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FC8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4FC8 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4fc8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Kluyveromyces_lactis_NRRL_Y-1140 Kluyveromyces lactis NRRL Y-1140]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FC8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4FC8 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">KLLA0F12672g, KLLA0_F12672g ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=284590 Candida sphaerica])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4fc8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fc8 OCA], [http://pdbe.org/4fc8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4fc8 RCSB], [http://www.ebi.ac.uk/pdbsum/4fc8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4fc8 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4fc8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fc8 OCA], [https://pdbe.org/4fc8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4fc8 RCSB], [https://www.ebi.ac.uk/pdbsum/4fc8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4fc8 ProSAT]</span></td></tr>
</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/Q6CK86_KLULA Q6CK86_KLULA]
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The activity of RNA polymerase II (Pol II) is controlled in part by the phosphorylation state of the C-terminal domain (CTD) of its largest subunit. Recent reports have suggested that yeast regulator of transcription protein, Rtr1, and its human homologue RPAP2, possess Pol II CTD Ser5 phosphatase activity. Here we report the crystal structure of Kluyveromyces lactis Rtr1, which reveals a new type of zinc finger protein and does not have any close structural homologues. Importantly, the structure does not show evidence of an active site, and extensive experiments to demonstrate its CTD phosphatase activity have been unsuccessful, suggesting that Rtr1 has a non-catalytic role in CTD dephosphorylation.
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The yeast regulator of transcription protein Rtr1 lacks an active site and phosphatase activity.,Xiang K, Manley JL, Tong L Nat Commun. 2012 Jul 10;3:946. doi: 10.1038/ncomms1947. PMID:22781759<ref>PMID:22781759</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 4fc8" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Candida sphaerica]]
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[[Category: Kluyveromyces lactis NRRL Y-1140]]
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[[Category: Tong, L]]
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[[Category: Large Structures]]
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[[Category: Xiang, K]]
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[[Category: Tong L]]
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[[Category: Transcription]]
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[[Category: Xiang K]]
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[[Category: Zinc finger]]
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Current revision

Crystal structure of transcription regulator protein Rtr1 from Kluyveromyces lactis

PDB ID 4fc8

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