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4nem
From Proteopedia
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==Small molecular fragment bound to crystal contact interface of Interleukin-2== | ==Small molecular fragment bound to crystal contact interface of Interleukin-2== | ||
| - | <StructureSection load='4nem' size='340' side='right' caption='[[4nem]], [[Resolution|resolution]] 1.93Å' scene=''> | + | <StructureSection load='4nem' size='340' side='right'caption='[[4nem]], [[Resolution|resolution]] 1.93Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4nem]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NEM OCA]. For a <b>guided tour on the structure components</b> use [ | + | <table><tr><td colspan='2'>[[4nem]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NEM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4NEM FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2JY:5-[(2,3-DICHLOROPHENOXY)METHYL]FURAN-2-CARBOXYLIC+ACID'>2JY</scene> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2JY:5-[(2,3-DICHLOROPHENOXY)METHYL]FURAN-2-CARBOXYLIC+ACID'>2JY</scene></td></tr> |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4nem FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nem OCA], [https://pdbe.org/4nem PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4nem RCSB], [https://www.ebi.ac.uk/pdbsum/4nem PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4nem ProSAT]</span></td></tr> | |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
| + | == Disease == | ||
| + | [https://www.uniprot.org/uniprot/IL2_HUMAN IL2_HUMAN] Note=A chromosomal aberration involving IL2 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with involves TNFRSF17. | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/IL2_HUMAN IL2_HUMAN] Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells. | ||
==See Also== | ==See Also== | ||
| - | *[[Interleukin|Interleukin]] | + | *[[Interleukin 3D structures|Interleukin 3D structures]] |
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Allen KN]] |
| - | [[Category: | + | [[Category: Brenke R]] |
| - | [[Category: | + | [[Category: Jehle S]] |
| - | [[Category: | + | [[Category: Kozakov D]] |
| - | [[Category: | + | [[Category: Vajda S]] |
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Current revision
Small molecular fragment bound to crystal contact interface of Interleukin-2
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Categories: Homo sapiens | Large Structures | Allen KN | Brenke R | Jehle S | Kozakov D | Vajda S
