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2xbk

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==X-RAY STRUCTURE OF THE SUBSTRATE-BOUND CYTOCHROME P450 PIMD - A POLYENE MACROLIDE ANTIBIOTIC PIMARICIN EPOXIDASE==
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==X-ray structure of the substrate-bound cytochrome P450 PimD - a polyene macrolide antibiotic pimaricin epoxidase==
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<StructureSection load='2xbk' size='340' side='right' caption='[[2xbk]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
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<StructureSection load='2xbk' size='340' side='right'caption='[[2xbk]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2xbk]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"streptomyces_natalensis"_struyk_et_al._1958 "streptomyces natalensis" struyk et al. 1958]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XBK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XBK FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2xbk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_natalensis Streptomyces natalensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XBK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XBK FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=XBK:4,5-DE-EPOXYPIMARICIN'>XBK</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2x9p|2x9p]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=XBK:4,5-DE-EPOXYPIMARICIN'>XBK</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xbk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xbk OCA], [http://pdbe.org/2xbk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2xbk RCSB], [http://www.ebi.ac.uk/pdbsum/2xbk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2xbk ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xbk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xbk OCA], [https://pdbe.org/2xbk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xbk RCSB], [https://www.ebi.ac.uk/pdbsum/2xbk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xbk ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q9EW92_9ACTN Q9EW92_9ACTN]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xb/2xbk_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xb/2xbk_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Streptomyces natalensis struyk et al. 1958]]
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[[Category: Large Structures]]
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[[Category: Aparicio, J F]]
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[[Category: Streptomyces natalensis]]
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[[Category: Kells, P M]]
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[[Category: Aparicio JF]]
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[[Category: Ouellet, H]]
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[[Category: Kells PM]]
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[[Category: Podust, L M]]
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[[Category: Ouellet H]]
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[[Category: Santos-Aberturas, J]]
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[[Category: Podust LM]]
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[[Category: Epoxidation]]
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[[Category: Santos-Aberturas J]]
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[[Category: Oxidoreductase]]
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Current revision

X-ray structure of the substrate-bound cytochrome P450 PimD - a polyene macrolide antibiotic pimaricin epoxidase

PDB ID 2xbk

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