2yii

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==Manipulating the regioselectivity of phenylalanine aminomutase: new insights into the reaction mechanism of MIO-dependent enzymes from structure-guided directed evolution==
==Manipulating the regioselectivity of phenylalanine aminomutase: new insights into the reaction mechanism of MIO-dependent enzymes from structure-guided directed evolution==
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<StructureSection load='2yii' size='340' side='right' caption='[[2yii]], [[Resolution|resolution]] 2.18&Aring;' scene=''>
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<StructureSection load='2yii' size='340' side='right'caption='[[2yii]], [[Resolution|resolution]] 2.18&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2yii]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Chinese_yew Chinese yew]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YII OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2YII FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2yii]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Taxus_chinensis Taxus chinensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YII OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YII FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.18&#8491;</td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MDO:{2-[(1S)-1-AMINOETHYL]-4-METHYLIDENE-5-OXO-4,5-DIHYDRO-1H-IMIDAZOL-1-YL}ACETIC+ACID'>MDO</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MDO:{2-[(1S)-1-AMINOETHYL]-4-METHYLIDENE-5-OXO-4,5-DIHYDRO-1H-IMIDAZOL-1-YL}ACETIC+ACID'>MDO</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2yii FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yii OCA], [http://pdbe.org/2yii PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2yii RCSB], [http://www.ebi.ac.uk/pdbsum/2yii PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2yii ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2yii FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yii OCA], [https://pdbe.org/2yii PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2yii RCSB], [https://www.ebi.ac.uk/pdbsum/2yii PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2yii ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PAM_TAXWC PAM_TAXWC] Phenylalanine aminomutase that catalyzes the rearrangement of L-phenylalanine to R-beta-phenylalanine. Catalyzes the first commited step in the biosynthesis of the side chain of the alkaloid taxol (paclitaxel), a widely-used compound with antitumor activity. Has also low phenylalanine ammonia-lyase activity and can catalyze the amination of trans-cinnamate.<ref>PMID:15878763</ref> <ref>PMID:22113970</ref> <ref>PMID:24786474</ref>
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<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
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*[[Aminomutase|Aminomutase]]
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*[[Aminomutase 3D structures|Aminomutase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Chinese yew]]
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[[Category: Large Structures]]
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[[Category: Bartsch, S]]
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[[Category: Taxus chinensis]]
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[[Category: Dijkstra, B W]]
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[[Category: Bartsch S]]
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[[Category: Feringa, B L]]
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[[Category: Dijkstra BW]]
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[[Category: Heberling, M M]]
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[[Category: Feringa BL]]
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[[Category: Janssen, D B]]
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[[Category: Heberling MM]]
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[[Category: Poelarends, G J]]
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[[Category: Janssen DB]]
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[[Category: Szymanski, W]]
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[[Category: Poelarends GJ]]
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[[Category: Wildeman, S]]
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[[Category: Szymanski W]]
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[[Category: Wu, B]]
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[[Category: Wildeman S]]
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[[Category: Wybenga, G G]]
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[[Category: Wu B]]
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[[Category: Lyase]]
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[[Category: Wybenga GG]]

Current revision

Manipulating the regioselectivity of phenylalanine aminomutase: new insights into the reaction mechanism of MIO-dependent enzymes from structure-guided directed evolution

PDB ID 2yii

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