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Structural highlights

Function

KIF14_MOUSE Microtubule motor protein that binds to microtubules with high affinity through each tubulin heterodimer and has an ATPase activity (PubMed:24949858). Plays a role in many processes like cell division, cytokinesis and also in cell proliferation and apoptosis (By similarity). During cytokinesis, targets to central spindle and midbody through its interaction with PRC1 and CIT respectively (By similarity). Regulates cell growth through regulation of cell cycle progression and cytokinesis. During cell cycle progression acts through SCF-dependent proteasomal ubiquitin-dependent protein catabolic process which controls CDKN1B degradation, resulting in positive regulation of cyclins, including CCNE1, CCND1 and CCNB1 (By similarity). During late neurogenesis, regulates the cerebellar and cerebral cortex development and olfactory bulb development through regulation of apoptosis, cell proliferation and cell division (PubMed:23308235, PubMed:24931760). Also is required for chromosome congression and alignment during mitotic cell cycle process (By similarity). Regulates cell spreading, focal adhesion dynamics, and cell migration through its interaction with RADIL resulting in regulation of RAP1A-mediated inside-out integrin activation by tethering RADIL on microtubules (By similarity).[UniProtKB:Q15058]^{[1] [2] [3]}

References

1. ↑ Fujikura K, Setsu T, Tanigaki K, Abe T, Kiyonari H, Terashima T, Sakisaka T. Kif14 mutation causes severe brain malformation and hypomyelination. PLoS One. 2013;8(1):e53490. doi: 10.1371/journal.pone.0053490. Epub 2013 Jan 4. PMID:23308235 doi:http://dx.doi.org/10.1371/journal.pone.0053490
2. ↑ Yunus J, Setsu T, Kikkawa S, Sakisaka T, Terashima T. Cytoarchitecture of the olfactory bulb in the laggard mutant mouse. Neuroscience. 2014 Sep 5;275:259-71. doi: 10.1016/j.neuroscience.2014.06.011. , Epub 2014 Jun 12. PMID:24931760 doi:http://dx.doi.org/10.1016/j.neuroscience.2014.06.011
3. ↑ Arora K, Talje L, Asenjo AB, Andersen P, Atchia K, Joshi M, Sosa H, Allingham JS, Kwok BH. KIF14 binds tightly to microtubules and adopts a rigor-like conformation. J Mol Biol. 2014 Jun 17. pii: S0022-2836(14)00282-4. doi:, 10.1016/j.jmb.2014.05.030. PMID:24949858 doi:http://dx.doi.org/10.1016/j.jmb.2014.05.030
4. ↑ Arora K, Talje L, Asenjo AB, Andersen P, Atchia K, Joshi M, Sosa H, Allingham JS, Kwok BH. KIF14 binds tightly to microtubules and adopts a rigor-like conformation. J Mol Biol. 2014 Jun 17. pii: S0022-2836(14)00282-4. doi:, 10.1016/j.jmb.2014.05.030. PMID:24949858 doi:http://dx.doi.org/10.1016/j.jmb.2014.05.030