4llq

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==Structure of redesigned IgG1 first constant and lambda domains (CH1:Clambda constant redesign 2 beta, CRD2b) at 1.42A==
==Structure of redesigned IgG1 first constant and lambda domains (CH1:Clambda constant redesign 2 beta, CRD2b) at 1.42A==
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<StructureSection load='4llq' size='340' side='right' caption='[[4llq]], [[Resolution|resolution]] 1.42&Aring;' scene=''>
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<StructureSection load='4llq' size='340' side='right'caption='[[4llq]], [[Resolution|resolution]] 1.42&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4llq]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LLQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4LLQ FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4llq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LLQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4LLQ FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PG6:1-(2-METHOXY-ETHOXY)-2-{2-[2-(2-METHOXY-ETHOXY]-ETHOXY}-ETHANE'>PG6</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.42&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4lld|4lld]], [[4llm|4llm]], [[4llu|4llu]], [[4llw|4llw]], [[4lly|4lly]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PG6:1-(2-METHOXY-ETHOXY)-2-{2-[2-(2-METHOXY-ETHOXY]-ETHOXY}-ETHANE'>PG6</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">DKFZp686G11190 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), IGL@ ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4llq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4llq OCA], [https://pdbe.org/4llq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4llq RCSB], [https://www.ebi.ac.uk/pdbsum/4llq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4llq ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4llq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4llq OCA], [http://pdbe.org/4llq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4llq RCSB], [http://www.ebi.ac.uk/pdbsum/4llq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4llq ProSAT]</span></td></tr>
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</table>
</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/IGHG1_HUMAN IGHG1_HUMAN] Defects in IGHG1 are a cause of multiple myeloma (MM) [MIM:[https://omim.org/entry/254500 254500]. MM is a malignant tumor of plasma cells usually arising in the bone marrow and characterized by diffuse involvement of the skeletal system, hyperglobulinemia, Bence-Jones proteinuria and anemia. Complications of multiple myeloma are bone pain, hypercalcemia, renal failure and spinal cord compression. The aberrant antibodies that are produced lead to impaired humoral immunity and patients have a high prevalence of infection. Amyloidosis may develop in some patients. Multiple myeloma is part of a spectrum of diseases ranging from monoclonal gammopathy of unknown significance (MGUS) to plasma cell leukemia. Note=A chromosomal aberration involving IGHG1 is found in multiple myeloma. Translocation t(11;14)(q13;q32) with the IgH locus. Translocation t(11;14)(q13;q32) with CCND1; translocation t(4;14)(p16.3;q32.3) with FGFR3; translocation t(6;14)(p25;q32) with IRF4.
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== Function ==
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[https://www.uniprot.org/uniprot/IGHG1_HUMAN IGHG1_HUMAN]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Atwell, S]]
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[[Category: Large Structures]]
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[[Category: Chamberlain, A K]]
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[[Category: Atwell S]]
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[[Category: Demarest, S J]]
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[[Category: Chamberlain AK]]
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[[Category: Guntas, G]]
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[[Category: Demarest SJ]]
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[[Category: Hansen-Estruch, C]]
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[[Category: Guntas G]]
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[[Category: Ho, C]]
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[[Category: Hansen-Estruch C]]
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[[Category: Huang, F]]
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[[Category: Ho C]]
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[[Category: Kuhlman, B]]
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[[Category: Huang F]]
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[[Category: Leaver-Fay, A]]
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[[Category: Kuhlman B]]
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[[Category: Lewis, S M]]
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[[Category: Leaver-Fay A]]
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[[Category: Pustilnik, A]]
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[[Category: Lewis SM]]
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[[Category: Sereno, A]]
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[[Category: Pustilnik A]]
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[[Category: Smith, E M]]
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[[Category: Sereno A]]
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[[Category: Truhlar, S M]]
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[[Category: Smith EM]]
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[[Category: Wu, X]]
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[[Category: Truhlar SM]]
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[[Category: Igg domain redesign]]
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[[Category: Wu X]]
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[[Category: Immune system]]
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Current revision

Structure of redesigned IgG1 first constant and lambda domains (CH1:Clambda constant redesign 2 beta, CRD2b) at 1.42A

PDB ID 4llq

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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