1nyc

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (08:00, 14 February 2024) (edit) (undo)
 
(10 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1nyc.jpg|left|200px]]
 
-
{{Structure
+
==Staphostatins resemble lipocalins, not cystatins in fold.==
-
|PDB= 1nyc |SIZE=350|CAPTION= <scene name='initialview01'>1nyc</scene>, resolution 1.40&Aring;
+
<StructureSection load='1nyc' size='340' side='right'caption='[[1nyc]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
-
|SITE=
+
== Structural highlights ==
-
|LIGAND= <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
+
<table><tr><td colspan='2'>[[1nyc]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus_MW2 Staphylococcus aureus subsp. aureus MW2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NYC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NYC FirstGlance]. <br>
-
|ACTIVITY=
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.4&#8491;</td></tr>
-
|GENE= staphostatin B (sspC) ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1280 Staphylococcus aureus])
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-
|DOMAIN=
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1nyc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nyc OCA], [https://pdbe.org/1nyc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1nyc RCSB], [https://www.ebi.ac.uk/pdbsum/1nyc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1nyc ProSAT]</span></td></tr>
-
|RELATEDENTRY=
+
</table>
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1nyc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nyc OCA], [http://www.ebi.ac.uk/pdbsum/1nyc PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1nyc RCSB]</span>
+
== Function ==
-
}}
+
[https://www.uniprot.org/uniprot/SSPC_STAAW SSPC_STAAW] Specifically inhibits the cysteine protease staphopain B (SspB) by blocking the active site of the enzyme. Probably required to protect cytoplasmic proteins from being degraded by prematurely activated/folded prostaphopain B. Also involved in growth capacity, viability and bacterial morphology (By similarity).
-
 
+
__TOC__
-
'''Staphostatins resemble lipocalins, not cystatins in fold.'''
+
</StructureSection>
-
 
+
[[Category: Large Structures]]
-
 
+
[[Category: Staphylococcus aureus subsp. aureus MW2]]
-
==Overview==
+
[[Category: Bochtler M]]
-
Staphostatins are the endogenous inhibitors of the major secreted cysteine proteases of Staphylococcus aureus, the staphopains. Here, we present the 1.4 A crystal structure of staphostatin B and show that the fold can be described as a fully closed, highly sheared eight-stranded beta-barrel. Thus, staphostatin B is related to beta-barrel domains that are involved in the inhibition or regulation of proteases of various catalytic types and to the superfamily of lipocalins/cytosolic fatty acid binding proteins. Unexpectedly for a cysteine protease inhibitor, staphostatin B is not significantly similar to cystatins.
+
[[Category: Dubin A]]
-
 
+
[[Category: Filipek R]]
-
==About this Structure==
+
[[Category: Kosowska K]]
-
1NYC is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NYC OCA].
+
[[Category: Potempa J]]
-
 
+
[[Category: Rzychon M]]
-
==Reference==
+
[[Category: Sabat A]]
-
Staphostatins resemble lipocalins, not cystatins in fold., Rzychon M, Filipek R, Sabat A, Kosowska K, Dubin A, Potempa J, Bochtler M, Protein Sci. 2003 Oct;12(10):2252-6. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/14500882 14500882]
+
-
[[Category: Single protein]]
+
-
[[Category: Staphylococcus aureus]]
+
-
[[Category: Bochtler, M.]]
+
-
[[Category: Dubin, A.]]
+
-
[[Category: Filipek, R.]]
+
-
[[Category: Kosowska, K.]]
+
-
[[Category: Potempa, J.]]
+
-
[[Category: Rzychon, M.]]
+
-
[[Category: Sabat, A.]]
+
-
[[Category: cysteine protease inhibitor]]
+
-
[[Category: sspc]]
+
-
[[Category: staphostatin b]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:37:13 2008''
+

Current revision

Staphostatins resemble lipocalins, not cystatins in fold.

PDB ID 1nyc

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1nyc"
Personal tools