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3aka

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Structural basis for prokaryotic calcium-mediated regulation by a Streptomyces coelicolor calcium-binding protein

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 ==Structural basis for prokaryotic calcium-mediated regulation by a Streptomyces coelicolor calcium-binding protein==
-<StructureSection load='3aka' size='340' side='right' caption='[[3aka]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
+<StructureSection load='3aka' size='340' side='right'caption='[[3aka]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[3aka]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Strco Strco]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AKA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3AKA FirstGlance]. <br>
+<table><tr><td colspan='2'>[[3aka]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_coelicolor_A3(2) Streptomyces coelicolor A3(2)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AKA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3AKA FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
-<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3akb|3akb]]</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
-<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">cabd, SC6F11.09, SCO4411 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=100226 STRCO])</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3aka FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3aka OCA], [https://pdbe.org/3aka PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3aka RCSB], [https://www.ebi.ac.uk/pdbsum/3aka PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3aka ProSAT]</span></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3aka FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3aka OCA], [http://pdbe.org/3aka PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3aka RCSB], [http://www.ebi.ac.uk/pdbsum/3aka PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3aka ProSAT]</span></td></tr>
 </table>
-<div style="background-color:#fffaf0;">
+== Function ==
-== Publication Abstract from PubMed ==
+[https://www.uniprot.org/uniprot/Q9F377_STRCO Q9F377_STRCO]
-The important and diverse regulatory roles of Ca(2+) in eukaryotes are conveyed by the EF-hand containing calmodulin superfamily. However, the calcium-regulatory proteins in prokaryotes are still poorly understood. In this study, we report the three-dimensional structure of the calcium-binding protein from Streptomyces coelicolor, named CabD, which shares low sequence homology with other known helix-loop-helix EF-hand proteins. The CabD structure should provide insights into the biological role of the prokaryotic calcium-binding proteins. The unusual structural features of CabD compared with prokaryotic EF-hand proteins and eukaryotic sarcoplasmic calcium-binding proteins, including the bending conformation of the first C-terminal alpha-helix, unpaired ligand-binding EF-hands and the lack of the extreme C-terminal loop region, suggest it may have a distinct and significant function in calcium-mediated bacterial physiological processes, and provide a structural basis for potential calcium-mediated regulatory roles in prokaryotes.
-Structural basis for prokaryotic calcium-mediated regulation by a Streptomyces coelicolor calcium binding protein.,Zhao X, Pang H, Wang S, Zhou W, Yang K, Bartlam M Protein Cell. 2010 Aug;1(8):771-9. Epub 2010 Aug 28. PMID:21203918<ref>PMID:21203918</ref>
-From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-</div>
-<div class="pdbe-citations 3aka" style="background-color:#fffaf0;"></div>
-== References ==
-<references/>
 __TOC__
 </StructureSection>
-[[Category: Strco]]
+[[Category: Large Structures]]
-[[Category: Bartlam, M]]
+[[Category: Bartlam M]]
-[[Category: Pang, H]]
+[[Category: Pang H]]
-[[Category: Wang, S]]
+[[Category: Wang S]]
-[[Category: Yang, K]]
+[[Category: Yang K]]
-[[Category: Zhao, X]]
+[[Category: Zhao X]]
-[[Category: Zhou, W]]
+[[Category: Zhou W]]
-[[Category: Calcium-binding protein]]
-[[Category: Ef-hand]]
-[[Category: Metal binding protein]]

3aka

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Structural basis for prokaryotic calcium-mediated regulation by a Streptomyces coelicolor calcium-binding protein

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