4q60

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==Crystal structure of a 4-hydroxyproline epimerase from Burkholderia Multivorans atcc 17616, target EFI-506586, open form, with bound pyrrole-2-carboxylate==
==Crystal structure of a 4-hydroxyproline epimerase from Burkholderia Multivorans atcc 17616, target EFI-506586, open form, with bound pyrrole-2-carboxylate==
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<StructureSection load='4q60' size='340' side='right' caption='[[4q60]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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<StructureSection load='4q60' size='340' side='right'caption='[[4q60]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4q60]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Q60 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4Q60 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4q60]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Burkholderia_multivorans_ATCC_17616 Burkholderia multivorans ATCC 17616]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Q60 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4Q60 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PYC:PYRROLE-2-CARBOXYLATE'>PYC</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Proline_racemase Proline racemase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.1.1.4 5.1.1.4] </span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PYC:PYRROLE-2-CARBOXYLATE'>PYC</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4q60 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4q60 OCA], [http://pdbe.org/4q60 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4q60 RCSB], [http://www.ebi.ac.uk/pdbsum/4q60 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4q60 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4q60 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4q60 OCA], [https://pdbe.org/4q60 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4q60 RCSB], [https://www.ebi.ac.uk/pdbsum/4q60 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4q60 ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/4HPE1_BURM1 4HPE1_BURM1] Catalyzes the epimerization of trans-4-hydroxy-L-proline (t4LHyp) to cis-4-hydroxy-D-proline (c4DHyp). Is likely involved in a degradation pathway that converts t4LHyp to alpha-ketoglutarate. Displays no proline racemase activity.<ref>PMID:24980702</ref>
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== References ==
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<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Proline racemase]]
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[[Category: Burkholderia multivorans ATCC 17616]]
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[[Category: Almo, S C]]
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[[Category: Large Structures]]
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[[Category: Bhosle, R]]
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[[Category: Al Obaidi N]]
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[[Category: Chowdhury, S]]
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[[Category: Almo SC]]
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[[Category: Efi, Enzyme Function Initiative]]
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[[Category: Bhosle R]]
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[[Category: Evans, B]]
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[[Category: Chowdhury S]]
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[[Category: Gerlt, J A]]
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[[Category: Evans B]]
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[[Category: Glenn, A S]]
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[[Category: Gerlt JA]]
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[[Category: Hammonds, J]]
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[[Category: Glenn AS]]
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[[Category: Hillerich, B]]
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[[Category: Hammonds J]]
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[[Category: Love, J]]
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[[Category: Hillerich B]]
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[[Category: Obaidi, N Al]]
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[[Category: Love J]]
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[[Category: Patskovsky, Y]]
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[[Category: Patskovsky Y]]
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[[Category: Seidel, R D]]
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[[Category: Seidel RD]]
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[[Category: Sojitra, S]]
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[[Category: Sojitra S]]
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[[Category: Stead, M]]
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[[Category: Stead M]]
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[[Category: Toro, R]]
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[[Category: Toro R]]
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[[Category: Washington, E]]
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[[Category: Washington E]]
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[[Category: Efi]]
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[[Category: Enzyme function initiative]]
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[[Category: Isomerase]]
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[[Category: Probable proline racemase]]
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[[Category: Proline racemase family]]
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[[Category: Structural genomic]]
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Current revision

Crystal structure of a 4-hydroxyproline epimerase from Burkholderia Multivorans atcc 17616, target EFI-506586, open form, with bound pyrrole-2-carboxylate

PDB ID 4q60

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OCA

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