3bob

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==Carbonic anhydrase from marine diatom Thalassiosira weissflogii- cadmium bound domain 2==
==Carbonic anhydrase from marine diatom Thalassiosira weissflogii- cadmium bound domain 2==
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<StructureSection load='3bob' size='340' side='right' caption='[[3bob]], [[Resolution|resolution]] 1.45&Aring;' scene=''>
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<StructureSection load='3bob' size='340' side='right'caption='[[3bob]], [[Resolution|resolution]] 1.45&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3bob]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Marine_diatom Marine diatom]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BOB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3BOB FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3bob]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Conticribra_weissflogii Conticribra weissflogii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BOB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3BOB FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.45&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">cdca1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=67004 Marine diatom])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Carbonate_dehydratase Carbonate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.1 4.2.1.1] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3bob FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bob OCA], [https://pdbe.org/3bob PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3bob RCSB], [https://www.ebi.ac.uk/pdbsum/3bob PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3bob ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3bob FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bob OCA], [http://pdbe.org/3bob PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3bob RCSB], [http://www.ebi.ac.uk/pdbsum/3bob PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3bob ProSAT]</span></td></tr>
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</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/Q50EL4_THAWE Q50EL4_THAWE]
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Carbonic anhydrase, a zinc enzyme found in organisms from all kingdoms, catalyses the reversible hydration of carbon dioxide and is used for inorganic carbon acquisition by phytoplankton. In the oceans, where zinc is nearly depleted, diatoms use cadmium as a catalytic metal atom in cadmium carbonic anhydrase (CDCA). Here we report the crystal structures of CDCA in four distinct forms: cadmium-bound, zinc-bound, metal-free and acetate-bound. Despite lack of sequence homology, CDCA is a structural mimic of a functional beta-carbonic anhydrase dimer, with striking similarity in the spatial organization of the active site residues. CDCA readily exchanges cadmium and zinc at its active site--an apparently unique adaptation to oceanic life that is explained by a stable opening of the metal coordinating site in the absence of metal. Given the central role of diatoms in exporting carbon to the deep sea, their use of cadmium in an enzyme critical for carbon acquisition establishes a remarkable link between the global cycles of cadmium and carbon.
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Structure and metal exchange in the cadmium carbonic anhydrase of marine diatoms.,Xu Y, Feng L, Jeffrey PD, Shi Y, Morel FM Nature. 2008 Mar 6;452(7183):56-61. PMID:18322527<ref>PMID:18322527</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3bob" style="background-color:#fffaf0;"></div>
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==See Also==
==See Also==
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*[[Carbonic anhydrase|Carbonic anhydrase]]
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*[[Carbonic anhydrase 3D structures|Carbonic anhydrase 3D structures]]
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Carbonate dehydratase]]
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[[Category: Conticribra weissflogii]]
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[[Category: Marine diatom]]
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[[Category: Large Structures]]
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[[Category: Feng, L]]
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[[Category: Feng L]]
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[[Category: Jeffrey, P D]]
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[[Category: Jeffrey PD]]
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[[Category: Morel, F M.M]]
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[[Category: Morel FMM]]
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[[Category: Shi, Y]]
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[[Category: Shi Y]]
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[[Category: Xu, Y]]
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[[Category: Xu Y]]
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[[Category: Cadmium-bound]]
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[[Category: Carbonic anhydrase]]
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[[Category: Lyase]]
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Current revision

Carbonic anhydrase from marine diatom Thalassiosira weissflogii- cadmium bound domain 2

PDB ID 3bob

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