4txy

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==Crystal structure of Vibrio cholerae DncV cyclic AMP-GMP synthase, a prokaryotic cGAS homolog==
==Crystal structure of Vibrio cholerae DncV cyclic AMP-GMP synthase, a prokaryotic cGAS homolog==
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<StructureSection load='4txy' size='340' side='right' caption='[[4txy]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
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<StructureSection load='4txy' size='340' side='right'caption='[[4txy]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4txy]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TXY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4TXY FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4txy]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Vibrio_cholerae_O1_biovar_El_Tor_str._N16961 Vibrio cholerae O1 biovar El Tor str. N16961]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TXY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4TXY FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.0001&#8491;</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cyclic_GMP-AMP_synthase Cyclic GMP-AMP synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.86 2.7.7.86] </span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4txy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4txy OCA], [http://pdbe.org/4txy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4txy RCSB], [http://www.ebi.ac.uk/pdbsum/4txy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4txy ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4txy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4txy OCA], [https://pdbe.org/4txy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4txy RCSB], [https://www.ebi.ac.uk/pdbsum/4txy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4txy ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/DNCV_VIBCH DNCV_VIBCH]] Catalyzes the synthesis of cyclic AMP-GMP from ATP and GTP. Is also able to produce c-di-AMP and c-di-GMP from ATP and GTP, respectively; however, c-AMP-GMP is the dominant molecule produced by DncV in vivo. Is required for efficient V.cholerae intestinal colonization, and down-regulates the colonization-influencing process of chemotaxis. Is not active with dATP, TTP, UTP, and CTP.
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[https://www.uniprot.org/uniprot/DNCV_VIBCH DNCV_VIBCH] Catalyzes the synthesis of cyclic AMP-GMP from ATP and GTP. Is also able to produce c-di-AMP and c-di-GMP from ATP and GTP, respectively; however, c-AMP-GMP is the dominant molecule produced by DncV in vivo. Is required for efficient V.cholerae intestinal colonization, and down-regulates the colonization-influencing process of chemotaxis. Is not active with dATP, TTP, UTP, and CTP.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
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*[[Cyclic GMP-AMP synthase|Cyclic GMP-AMP synthase]]
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*[[Cyclic GMP-AMP synthase 3D synthase|Cyclic GMP-AMP synthase 3D synthase]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Cyclic GMP-AMP synthase]]
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[[Category: Large Structures]]
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[[Category: Berger, J M]]
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[[Category: Vibrio cholerae O1 biovar El Tor str. N16961]]
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[[Category: Doudna, J A]]
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[[Category: Berger JM]]
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[[Category: Kranzusch, P J]]
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[[Category: Doudna JA]]
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[[Category: Lee, A S.Y]]
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[[Category: Kranzusch PJ]]
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[[Category: Solovykh, M S]]
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[[Category: Lee ASY]]
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[[Category: Vance, R E]]
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[[Category: Solovykh MS]]
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[[Category: Wilson, S C]]
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[[Category: Vance RE]]
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[[Category: Cga]]
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[[Category: Wilson SC]]
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[[Category: Cyclic nucleotide synthase]]
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[[Category: Nucleotidyl transferase]]
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Current revision

Crystal structure of Vibrio cholerae DncV cyclic AMP-GMP synthase, a prokaryotic cGAS homolog

PDB ID 4txy

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