399d

<StructureSection load='399d' size='340' side='right' caption='[[399d]], [[Resolution|resolution]] 1.90&Aring;' scene=''>

<table><tr><td colspan='2'>[[399d]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=399D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=399D FirstGlance]. <br>

</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=399d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=399d OCA], [http://pdbe.org/399d PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=399d RCSB], [http://www.ebi.ac.uk/pdbsum/399d PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=399d ProSAT]</span></td></tr>

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== Publication Abstract from PubMed ==

We have determined the structure of the dodecamer duplex d(CGCCCGCGGGCG)2. A careful use of the molecular replacement programme AMoRe has been essential in order to solve the structure. This dodecamer shows a unique conformation, quite different from all the previously studied oligonucleotide duplexes: the central octamer has an A conformation, but with a sharp 65 degrees kink in the centre; the terminal base-steps have a B-like conformation; the major groove is completely closed in the centre, a hollow molecule is thus found. The results obtained confirm the high degree of variability of DNA structure. A new type of kink and an intermediate A/B double-helical conformation have been found. Such intermediate conformation differs from those described in DNA polymerase complexes.

Structure of the d(CGCCCGCGGGCG) dodecamer: a kinked A-DNA molecule showing some B-DNA features.,Malinina L, Fernandez LG, Huynh-Dinh T, Subirana JA J Mol Biol. 1999 Jan 29;285(4):1679-90. PMID:9917405<ref>PMID:9917405</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>

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<div class="pdbe-citations 399d" style="background-color:#fffaf0;"></div>

== References ==

<references/>

[[Category: Fernandez, L G]]

[[Category: Malinina, J A.Subirana L]]

[[Category: Dna]]

[[Category: Double helix]]