4gc0

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==The structure of the MFS (major facilitator superfamily) proton:xylose symporter XylE bound to 6-bromo-6-deoxy-D-glucose==
==The structure of the MFS (major facilitator superfamily) proton:xylose symporter XylE bound to 6-bromo-6-deoxy-D-glucose==
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<StructureSection load='4gc0' size='340' side='right' caption='[[4gc0]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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<StructureSection load='4gc0' size='340' side='right'caption='[[4gc0]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4gc0]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GC0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GC0 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4gc0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GC0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GC0 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6BG:6-BROMO-6-DEOXY-BETA-D-GLUCOPYRANOSE'>6BG</scene>, <scene name='pdbligand=BNG:B-NONYLGLUCOSIDE'>BNG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4gby|4gby]], [[4gbz|4gbz]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6BG:6-BROMO-6-DEOXY-BETA-D-GLUCOPYRANOSE'>6BG</scene>, <scene name='pdbligand=BNG:B-NONYLGLUCOSIDE'>BNG</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">xylE, b4031, JW3991 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gc0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gc0 OCA], [https://pdbe.org/4gc0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gc0 RCSB], [https://www.ebi.ac.uk/pdbsum/4gc0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gc0 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4gc0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gc0 OCA], [http://pdbe.org/4gc0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4gc0 RCSB], [http://www.ebi.ac.uk/pdbsum/4gc0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4gc0 ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/XYLE_ECOLI XYLE_ECOLI]] Uptake of D-xylose across the boundary membrane with the concomitant transport of protons into the cell (symport system).
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[https://www.uniprot.org/uniprot/XYLE_ECOLI XYLE_ECOLI] Uptake of D-xylose across the boundary membrane with the concomitant transport of protons into the cell (symport system).
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Glucose transporters are essential for metabolism of glucose in cells of diverse organisms from microbes to humans, exemplified by the disease-related human proteins GLUT1, 2, 3 and 4. Despite rigorous efforts, the structural information for GLUT1-4 or their homologues remains largely unknown. Here we report three related crystal structures of XylE, an Escherichia coli homologue of GLUT1-4, in complex with d-xylose, d-glucose and 6-bromo-6-deoxy-D-glucose, at resolutions of 2.8, 2.9 and 2.6 A, respectively. The structure consists of a typical major facilitator superfamily fold of 12 transmembrane segments and a unique intracellular four-helix domain. XylE was captured in an outward-facing, partly occluded conformation. Most of the important amino acids responsible for recognition of D-xylose or d-glucose are invariant in GLUT1-4, suggesting functional and mechanistic conservations. Structure-based modelling of GLUT1-4 allows mapping and interpretation of disease-related mutations. The structural and biochemical information reported here constitutes an important framework for mechanistic understanding of glucose transporters and sugar porters in general.
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Crystal structure of a bacterial homologue of glucose transporters GLUT1-4.,Sun L, Zeng X, Yan C, Sun X, Gong X, Rao Y, Yan N Nature. 2012 Oct 18;490(7420):361-6. doi: 10.1038/nature11524. PMID:23075985<ref>PMID:23075985</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 4gc0" style="background-color:#fffaf0;"></div>
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==See Also==
==See Also==
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*[[Symporter|Symporter]]
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*[[Symporter 3D structures|Symporter 3D structures]]
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Ecoli]]
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[[Category: Escherichia coli K-12]]
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[[Category: Sun, L F]]
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[[Category: Large Structures]]
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[[Category: Yan, C Y]]
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[[Category: Sun LF]]
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[[Category: Yan, N]]
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[[Category: Yan CY]]
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[[Category: Zeng, X]]
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[[Category: Yan N]]
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[[Category: D-xylose:proton symporter]]
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[[Category: Zeng X]]
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[[Category: Mf]]
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[[Category: Transport protein]]
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Current revision

The structure of the MFS (major facilitator superfamily) proton:xylose symporter XylE bound to 6-bromo-6-deoxy-D-glucose

PDB ID 4gc0

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