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2v9r

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==FIRST AND SECOND IG DOMAINS FROM HUMAN ROBO1 (FORM 2)==
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==First and second Ig domains from human Robo1 (Form 2)==
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<StructureSection load='2v9r' size='340' side='right' caption='[[2v9r]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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<StructureSection load='2v9r' size='340' side='right'caption='[[2v9r]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2v9r]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V9R OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2V9R FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2v9r]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V9R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2V9R FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2v9q|2v9q]], [[2v9s|2v9s]], [[2v9t|2v9t]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2v9r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v9r OCA], [http://pdbe.org/2v9r PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2v9r RCSB], [http://www.ebi.ac.uk/pdbsum/2v9r PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2v9r ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2v9r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v9r OCA], [https://pdbe.org/2v9r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2v9r RCSB], [https://www.ebi.ac.uk/pdbsum/2v9r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2v9r ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ROBO1_HUMAN ROBO1_HUMAN] Receptor for SLIT1 and SLIT2 which are thought to act as molecular guidance cue in cellular migration, including axonal navigation at the ventral midline of the neural tube and projection of axons to different regions during neuronal development. In axon growth cones, the silencing of the attractive effect of NTN1 by SLIT2 may require the formation of a ROBO1-DCC complex. May be required for lung development.<ref>PMID:10102268</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/v9/2v9r_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/v9/2v9r_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Cusack, S]]
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[[Category: Large Structures]]
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[[Category: Mccarthy, A A]]
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[[Category: Cusack S]]
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[[Category: Morlot, C]]
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[[Category: McCarthy AA]]
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[[Category: Chemotaxis]]
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[[Category: Morlot C]]
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[[Category: Developmental protein]]
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[[Category: Differentiation]]
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[[Category: Disease mutation]]
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[[Category: Glycoprotein]]
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[[Category: Ig domain]]
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[[Category: Immunoglobulin domain]]
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[[Category: Membrane]]
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[[Category: Neurogenesis]]
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[[Category: Neuronal development]]
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[[Category: Phosphorylation]]
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[[Category: Proto-oncogene]]
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[[Category: Receptor]]
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[[Category: Robo1]]
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[[Category: Roundabout]]
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[[Category: Transmembrane]]
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Current revision

First and second Ig domains from human Robo1 (Form 2)

PDB ID 2v9r

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