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4a2w

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==STRUCTURE OF FULL-LENGTH DUCK RIG-I==
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==Structure of full-length duck RIG-I==
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<StructureSection load='4a2w' size='340' side='right' caption='[[4a2w]], [[Resolution|resolution]] 3.70&Aring;' scene=''>
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<StructureSection load='4a2w' size='340' side='right'caption='[[4a2w]], [[Resolution|resolution]] 3.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4a2w]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Anapl Anapl]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A2W OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4A2W FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4a2w]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Anas_platyrhynchos Anas platyrhynchos]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A2W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4A2W FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4a2p|4a2p]], [[4a2v|4a2v]], [[4a2x|4a2x]], [[4a36|4a36]], [[4a2q|4a2q]]</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.7&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4a2w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a2w OCA], [http://pdbe.org/4a2w PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4a2w RCSB], [http://www.ebi.ac.uk/pdbsum/4a2w PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4a2w ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4a2w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a2w OCA], [https://pdbe.org/4a2w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4a2w RCSB], [https://www.ebi.ac.uk/pdbsum/4a2w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4a2w ProSAT]</span></td></tr>
</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/D3TI84_ANAPL D3TI84_ANAPL]
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RIG-I is a key innate immune pattern-recognition receptor that triggers interferon expression upon detection of intracellular 5'triphosphate double-stranded RNA (5'ppp-dsRNA) of viral origin. RIG-I comprises N-terminal caspase activation and recruitment domains (CARDs), a DECH helicase, and a C-terminal domain (CTD). We present crystal structures of the ligand-free, autorepressed, and RNA-bound, activated states of RIG-I. Inactive RIG-I has an open conformation with the CARDs sequestered by a helical domain inserted between the two helicase moieties. ATP and dsRNA binding induce a major rearrangement to a closed conformation in which the helicase and CTD bind the blunt end 5'ppp-dsRNA with perfect complementarity but incompatibly with continued CARD binding. We propose that after initial binding of 5'ppp-dsRNA to the flexibly linked CTD, co-operative tight binding of ATP and RNA to the helicase domain liberates the CARDs for downstream signaling. These findings significantly advance our molecular understanding of the activation of innate immune signaling helicases.
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Structural Basis for the Activation of Innate Immune Pattern-Recognition Receptor RIG-I by Viral RNA.,Kowalinski E, Lunardi T, McCarthy AA, Louber J, Brunel J, Grigorov B, Gerlier D, Cusack S Cell. 2011 Oct 14;147(2):423-35. PMID:22000019<ref>PMID:22000019</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 4a2w" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Anapl]]
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[[Category: Anas platyrhynchos]]
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[[Category: Cusack, S]]
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[[Category: Large Structures]]
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[[Category: Kowalinski, E]]
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[[Category: Cusack S]]
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[[Category: Lunardi, T]]
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[[Category: Kowalinski E]]
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[[Category: Mccarthy, A A]]
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[[Category: Lunardi T]]
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[[Category: Antiviral signalling pathway]]
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[[Category: McCarthy AA]]
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[[Category: Atp and dsrna binding]]
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[[Category: Card]]
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[[Category: Hydrolase]]
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[[Category: Superfamily 2 rna helicase]]
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Current revision

Structure of full-length duck RIG-I

PDB ID 4a2w

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