4pkd

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==U1-70k in complex with U1 snRNA stem-loops 1 and U1-A RRM in complex with stem-loop 2==
==U1-70k in complex with U1 snRNA stem-loops 1 and U1-A RRM in complex with stem-loop 2==
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<StructureSection load='4pkd' size='340' side='right' caption='[[4pkd]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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<StructureSection load='4pkd' size='340' side='right'caption='[[4pkd]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4pkd]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PKD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PKD FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4pkd]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PKD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4PKD FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3cw1|3cw1]], [[1urn|1urn]], [[3pgw|3pgw]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4pkd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pkd OCA], [https://pdbe.org/4pkd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4pkd RCSB], [https://www.ebi.ac.uk/pdbsum/4pkd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4pkd ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pkd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pkd OCA], [http://pdbe.org/4pkd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4pkd RCSB], [http://www.ebi.ac.uk/pdbsum/4pkd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4pkd ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/SNRPA_PIG SNRPA_PIG]] Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. U1 snRNP is the first snRNP to interact with pre-mRNA. This interaction is required for the subsequent binding of U2 snRNP and the U4/U6/U5 tri-snRNP. SNRPA binds stem loop II of U1 snRNA. In a snRNP-free form (SF-A) may be involved in coupled pre-mRNA splicing and polyadenylation process. May bind preferentially to the 5'-UGCAC-3' motif on RNAs (By similarity).
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[https://www.uniprot.org/uniprot/RU17_HUMAN RU17_HUMAN] Mediates the splicing of pre-mRNA by binding to the loop I region of U1-snRNA. The truncated isoforms cannot bind U1-snRNA.[https://www.uniprot.org/uniprot/SNRPA_PIG SNRPA_PIG] Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. U1 snRNP is the first snRNP to interact with pre-mRNA. This interaction is required for the subsequent binding of U2 snRNP and the U4/U6/U5 tri-snRNP. SNRPA binds stem loop II of U1 snRNA. In a snRNP-free form (SF-A) may be involved in coupled pre-mRNA splicing and polyadenylation process. May bind preferentially to the 5'-UGCAC-3' motif on RNAs (By similarity).
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<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Kondo, Y]]
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[[Category: Homo sapiens]]
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[[Category: Nagai, K]]
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[[Category: Large Structures]]
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[[Category: Oubridge, C]]
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[[Category: Sus scrofa]]
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[[Category: Roon, A M.van]]
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[[Category: Kondo Y]]
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[[Category: Gene regulation]]
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[[Category: Nagai K]]
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[[Category: Pre-mrna splicing]]
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[[Category: Oubridge C]]
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[[Category: Spliceosome]]
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[[Category: Van Roon AM]]
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[[Category: U1 snrnp]]
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[[Category: U1-70k]]
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Current revision

U1-70k in complex with U1 snRNA stem-loops 1 and U1-A RRM in complex with stem-loop 2

PDB ID 4pkd

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