2wl7

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==CRYSTAL STRUCTURE OF THE PSD93 PDZ1 DOMAIN==
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==Crystal structure of the PSD93 PDZ1 domain==
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<StructureSection load='2wl7' size='340' side='right' caption='[[2wl7]], [[Resolution|resolution]] 2.03&Aring;' scene=''>
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<StructureSection load='2wl7' size='340' side='right'caption='[[2wl7]], [[Resolution|resolution]] 2.03&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2wl7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WL7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WL7 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2wl7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WL7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WL7 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.028&#8491;</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Guanylate_kinase Guanylate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.4.8 2.7.4.8] </span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wl7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wl7 OCA], [http://pdbe.org/2wl7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2wl7 RCSB], [http://www.ebi.ac.uk/pdbsum/2wl7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2wl7 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wl7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wl7 OCA], [https://pdbe.org/2wl7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wl7 RCSB], [https://www.ebi.ac.uk/pdbsum/2wl7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wl7 ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/DLG2_MOUSE DLG2_MOUSE] Required for perception of chronic pain through NMDA receptor signaling. Regulates surface expression of NMDA receptors in dorsal horn neurons of the spinal cord. Interacts with the cytoplasmic tail of NMDA receptor subunits as well as inward rectifying potassium channels. Involved in regulation of synaptic stability at cholinergic synapses. Part of the postsynaptic protein scaffold of excitatory synapses.<ref>PMID:12890763</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wl/2wl7_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wl/2wl7_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
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</div>
</div>
<div class="pdbe-citations 2wl7" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 2wl7" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Postsynaptic density protein 3D structures|Postsynaptic density protein 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Guanylate kinase]]
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[[Category: Large Structures]]
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[[Category: Lk3 transgenic mice]]
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[[Category: Mus musculus]]
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[[Category: Fiorentini, M]]
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[[Category: Fiorentini M]]
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[[Category: Gajhede, M]]
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[[Category: Gajhede M]]
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[[Category: Kallehauge, A]]
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[[Category: Kallehauge A]]
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[[Category: Kastrup, J S]]
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[[Category: Kastrup JS]]
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[[Category: Kristensen, O]]
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[[Category: Kristensen O]]
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[[Category: Chapsyn-110]]
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[[Category: Delta2 receptor interacting protein]]
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[[Category: Dlg2]]
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[[Category: Maguk]]
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[[Category: Pdz domain]]
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[[Category: Psd93]]
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[[Category: Transferase]]
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Current revision

Crystal structure of the PSD93 PDZ1 domain

PDB ID 2wl7

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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