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3fmp

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==Crystal structure of the nucleoporin Nup214 in complex with the DEAD-box helicase Ddx19==
==Crystal structure of the nucleoporin Nup214 in complex with the DEAD-box helicase Ddx19==
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<StructureSection load='3fmp' size='340' side='right' caption='[[3fmp]], [[Resolution|resolution]] 3.19&Aring;' scene=''>
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<StructureSection load='3fmp' size='340' side='right'caption='[[3fmp]], [[Resolution|resolution]] 3.19&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3fmp]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FMP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3FMP FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3fmp]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FMP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3FMP FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.19&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3fmo|3fmo]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NUP214, CAIN, CAN, KIAA0023 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), DDX19B, DBP5, DDX19 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3fmp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fmp OCA], [https://pdbe.org/3fmp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3fmp RCSB], [https://www.ebi.ac.uk/pdbsum/3fmp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3fmp ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3fmp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fmp OCA], [http://pdbe.org/3fmp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3fmp RCSB], [http://www.ebi.ac.uk/pdbsum/3fmp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3fmp ProSAT]</span></td></tr>
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</table>
</table>
== Disease ==
== Disease ==
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[[http://www.uniprot.org/uniprot/NU214_HUMAN NU214_HUMAN]] Note=A chromosomal aberration involving NUP214 is found in a subset of acute myeloid leukemia (AML); also known as acute non-lymphocytic leukemia. Translocation t(6;9)(p23;q34) with DEK. It results in the formation of a DEK-CAN fusion gene. Note=A chromosomal aberration involving NUP214 is found in some cases of acute undifferentiated leukemia (AUL). Translocation t(6;9)(q21;q34.1) with SET.
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[https://www.uniprot.org/uniprot/NU214_HUMAN NU214_HUMAN] Note=A chromosomal aberration involving NUP214 is found in a subset of acute myeloid leukemia (AML); also known as acute non-lymphocytic leukemia. Translocation t(6;9)(p23;q34) with DEK. It results in the formation of a DEK-CAN fusion gene. Note=A chromosomal aberration involving NUP214 is found in some cases of acute undifferentiated leukemia (AUL). Translocation t(6;9)(q21;q34.1) with SET.
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/NU214_HUMAN NU214_HUMAN]] May serve as a docking site in the receptor-mediated import of substrates across the nuclear pore complex. [[http://www.uniprot.org/uniprot/DD19B_HUMAN DD19B_HUMAN]] ATP-dependent RNA helicase involved in mRNA export from the nucleus. Rather than unwinding RNA duplexes, DDX19B functions as a remodeler of ribonucleoprotein particles, whereby proteins bound to nuclear mRNA are dissociated and replaced by cytoplasmic mRNA binding proteins.
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[https://www.uniprot.org/uniprot/NU214_HUMAN NU214_HUMAN] May serve as a docking site in the receptor-mediated import of substrates across the nuclear pore complex.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fm/3fmp_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fm/3fmp_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
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==See Also==
==See Also==
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*[[Helicase|Helicase]]
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*[[Helicase 3D structures|Helicase 3D structures]]
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*[[Nucleoporin|Nucleoporin]]
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*[[Nucleoporin 3D structures|Nucleoporin 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Blobel, G]]
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[[Category: Large Structures]]
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[[Category: Debler, E W]]
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[[Category: Blobel G]]
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[[Category: Hoelz, A]]
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[[Category: Debler EW]]
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[[Category: Napetschnig, J]]
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[[Category: Hoelz A]]
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[[Category: Atp-binding]]
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[[Category: Napetschnig J]]
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[[Category: Beta-propeller]]
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[[Category: Dead box]]
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[[Category: Glycoprotein]]
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[[Category: Helicase]]
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[[Category: Hydrolase]]
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[[Category: Membrane]]
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[[Category: Mrna export]]
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[[Category: Mrna transport]]
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[[Category: Nuclear pore complex]]
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[[Category: Nuclear porin]]
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[[Category: Nucleocytoplasmic transport]]
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[[Category: Nucleotide-binding]]
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[[Category: Nucleus]]
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[[Category: Oncoprotein-hydrolase complex]]
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[[Category: Phosphoprotein]]
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[[Category: Protein interaction]]
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[[Category: Protein transport]]
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[[Category: Protein transport-hydrolase complex]]
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[[Category: Proto-oncogene]]
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[[Category: Rna-binding]]
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[[Category: Translocation]]
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[[Category: Transport]]
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Current revision

Crystal structure of the nucleoporin Nup214 in complex with the DEAD-box helicase Ddx19

PDB ID 3fmp

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