3v07

<StructureSection load='3v07' size='340' side='right' caption='[[3v07]], [[Resolution|resolution]] 1.24&Aring;' scene=''>

<table><tr><td colspan='2'>[[3v07]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V07 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3V07 FirstGlance]. <br>

</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=F6H:3,7-ANHYDRO-1,5,6-TRIDEOXY-5-FLUORO-6-(5-METHYL-2,4-DIOXO-3,4-DIHYDROPYRIMIDIN-1(2H)-YL)-2-O-PHOSPHONO-D-GLYCERO-L-ALLO-HEPTITOL'>F6H</scene></td></tr>

<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3v06|3v06]]</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3v07 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v07 OCA], [http://pdbe.org/3v07 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3v07 RCSB], [http://www.ebi.ac.uk/pdbsum/3v07 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3v07 ProSAT]</span></td></tr>

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== Publication Abstract from PubMed ==

Locked nucleic acid (LNA) analogues with 2',4'-bridged sugars show promise in antisense applications. S-5'-Me-LNA has high RNA affinity, and modified oligonucleotides show weakened immune stimulation in vivo. Conversely, an R-5'-methyl group dramatically lowers RNA affinity. To test the effects of S- and R-6'-methyl groups on 3'-fluoro hexitol nucleic acid (FHNA) stability, we synthesized S- and R-6'-Me-FHNA thymidine and incorporated them into oligo-2'-deoxynucleotides. As with LNA, S-6'-Me is stabilizing whereas R-6'-Me is destabilizing. Crystal structures of 6'-Me-FHNA-modified DNAs explain the divergent consequences for stability and suggest convergent origins of these effects by S- and R-6'-Me (FHNA) [-5'-Me (LNA and RNA)] substituents.

Insights from crystal structures into the opposite effects on RNA affinity caused by the s- and R-6'-methyl backbone modifications of 3'-fluoro hexitol nucleic Acid.,Pallan PS, Yu J, Allerson CR, Swayze EE, Seth P, Egli M Biochemistry. 2012 Jan 10;51(1):7-9. Epub 2011 Dec 29. PMID:22229409<ref>PMID:22229409</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>

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<div class="pdbe-citations 3v07" style="background-color:#fffaf0;"></div>

== References ==

<references/>

[[Category: Egli, M]]

[[Category: Pallan, P S]]

[[Category: 3'-fluoro hexitol nucleic acid]]

[[Category: R-6'-me-fhna]]