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4kxx

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==Human transketolase in covalent complex with donor ketose D-sedoheptulose-7-phosphate==
==Human transketolase in covalent complex with donor ketose D-sedoheptulose-7-phosphate==
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<StructureSection load='4kxx' size='340' side='right' caption='[[4kxx]], [[Resolution|resolution]] 1.03&Aring;' scene=''>
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<StructureSection load='4kxx' size='340' side='right'caption='[[4kxx]], [[Resolution|resolution]] 1.03&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4kxx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KXX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4KXX FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4kxx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KXX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4KXX FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1Y7:(2R,3R,4S,5R,6S)-2,3,4,5,6,7-HEXAHYDROXYHEPTYL+DIHYDROGEN+PHOSPHATE'>1Y7</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=TDP:THIAMIN+DIPHOSPHATE'>TDP</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.03&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TKT ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1Y7:(2R,3R,4S,5R,6S)-2,3,4,5,6,7-HEXAHYDROXYHEPTYL+DIHYDROGEN+PHOSPHATE'>1Y7</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=TPP:THIAMINE+DIPHOSPHATE'>TPP</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Transketolase Transketolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.2.1.1 2.2.1.1] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4kxx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kxx OCA], [https://pdbe.org/4kxx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4kxx RCSB], [https://www.ebi.ac.uk/pdbsum/4kxx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4kxx ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4kxx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kxx OCA], [http://pdbe.org/4kxx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4kxx RCSB], [http://www.ebi.ac.uk/pdbsum/4kxx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4kxx ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/TKT_HUMAN TKT_HUMAN]] Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.
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[https://www.uniprot.org/uniprot/TKT_HUMAN TKT_HUMAN] Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
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*[[Transketolase|Transketolase]]
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*[[Transketolase 3D structures|Transketolase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Transketolase]]
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[[Category: Large Structures]]
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[[Category: Ficner, R]]
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[[Category: Ficner R]]
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[[Category: Luedtke, S]]
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[[Category: Luedtke S]]
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[[Category: Neumann, P]]
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[[Category: Neumann P]]
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[[Category: Tittmann, K]]
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[[Category: Tittmann K]]
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[[Category: Enzyme catalysis]]
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[[Category: Pentose phosphate pathway]]
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[[Category: Thiamin diphosphate]]
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[[Category: Transferase]]
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Current revision

Human transketolase in covalent complex with donor ketose D-sedoheptulose-7-phosphate

PDB ID 4kxx

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