4cqj

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (12:14, 20 December 2023) (edit) (undo)
 
(2 intermediate revisions not shown.)
Line 1: Line 1:
==Fluorinase substrate flexibility enables last step aqueous and ambient 18F fluorination of a RGD peptide for positron emission tomography==
==Fluorinase substrate flexibility enables last step aqueous and ambient 18F fluorination of a RGD peptide for positron emission tomography==
-
<StructureSection load='4cqj' size='340' side='right' caption='[[4cqj]], [[Resolution|resolution]] 2.44&Aring;' scene=''>
+
<StructureSection load='4cqj' size='340' side='right'caption='[[4cqj]], [[Resolution|resolution]] 2.44&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[4cqj]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CQJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CQJ FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[4cqj]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_cattleya Streptomyces cattleya]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CQJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4CQJ FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EFA:5-DEOXY-2-ETHYNYL-5-FLUOROADENOSINE'>EFA</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.44&#8491;</td></tr>
-
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Adenosyl-fluoride_synthase Adenosyl-fluoride synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.63 2.5.1.63] </span></td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EFA:5-DEOXY-2-ETHYNYL-5-FLUOROADENOSINE'>EFA</scene></td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4cqj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cqj OCA], [http://pdbe.org/4cqj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4cqj RCSB], [http://www.ebi.ac.uk/pdbsum/4cqj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4cqj ProSAT]</span></td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4cqj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cqj OCA], [https://pdbe.org/4cqj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4cqj RCSB], [https://www.ebi.ac.uk/pdbsum/4cqj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4cqj ProSAT]</span></td></tr>
</table>
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/FLA_STRCT FLA_STRCT] Involved in the biosynthesis of fluorometabolites. Catalyzes the formation of a C-F bond by combining S-adenosyl-L-methionine (SAM) and fluoride to generate 5'-fluoro-5'-deoxyadenosine (5'-FDA) and L-methionine. It can also use 2'-deoxyadenosine in place of adenosine as substrate.<ref>PMID:12860396</ref> <ref>PMID:14765200</ref> <ref>PMID:16370017</ref> <ref>PMID:16604208</ref> <ref>PMID:16720268</ref> <ref>PMID:17985882</ref>
 +
== References ==
 +
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Adenosyl-fluoride synthase]]
+
[[Category: Large Structures]]
-
[[Category: Hagan, D O]]
+
[[Category: Streptomyces cattleya]]
-
[[Category: McMahon, S A]]
+
[[Category: McMahon SA]]
-
[[Category: Naismith, J H]]
+
[[Category: Naismith JH]]
-
[[Category: Thompson, S]]
+
[[Category: O'Hagan D]]
-
[[Category: Transferase]]
+
[[Category: Thompson S]]

Current revision

Fluorinase substrate flexibility enables last step aqueous and ambient 18F fluorination of a RGD peptide for positron emission tomography

PDB ID 4cqj

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4cqj"
Personal tools