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4rcd

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==Crystal structure of BACE1 in complex with a 2-aminooxazoline 4-azaxanthene inhibitor==
==Crystal structure of BACE1 in complex with a 2-aminooxazoline 4-azaxanthene inhibitor==
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<StructureSection load='4rcd' size='340' side='right' caption='[[4rcd]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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<StructureSection load='4rcd' size='340' side='right'caption='[[4rcd]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4rcd]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RCD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4RCD FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4rcd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RCD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4RCD FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3LL:(5S)-7-(2-FLUOROPYRIDIN-3-YL)-3-[(3-METHYLOXETAN-3-YL)ETHYNYL]SPIRO[CHROMENO[2,3-B]PYRIDINE-5,4-[1,3]OXAZOL]-2-AMINE'>3LL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3LL:(5S)-7-(2-FLUOROPYRIDIN-3-YL)-3-[(3-METHYLOXETAN-3-YL)ETHYNYL]SPIRO[CHROMENO[2,3-B]PYRIDINE-5,4-[1,3]OXAZOL]-2-AMINE'>3LL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4rce|4rce]], [[4rcf|4rcf]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4rcd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rcd OCA], [https://pdbe.org/4rcd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4rcd RCSB], [https://www.ebi.ac.uk/pdbsum/4rcd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4rcd ProSAT]</span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4rcd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rcd OCA], [http://pdbe.org/4rcd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4rcd RCSB], [http://www.ebi.ac.uk/pdbsum/4rcd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4rcd ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN]] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref>
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[https://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
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*[[Beta secretase|Beta secretase]]
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*[[Beta secretase 3D structures|Beta secretase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Memapsin 2]]
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[[Category: Homo sapiens]]
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[[Category: Long, A M]]
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[[Category: Large Structures]]
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[[Category: Whittington, D A]]
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[[Category: Long AM]]
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[[Category: Alzheimer's disease]]
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[[Category: Whittington DA]]
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[[Category: Amyloid precursor protein]]
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[[Category: App]]
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[[Category: Aspartyl protease]]
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[[Category: Brain]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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Current revision

Crystal structure of BACE1 in complex with a 2-aminooxazoline 4-azaxanthene inhibitor

PDB ID 4rcd

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