1oaq

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[[Image:1oaq.jpg|left|200px]]
 
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{{Structure
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==Free conformation Ab1 of the IgE SPE-7==
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|PDB= 1oaq |SIZE=350|CAPTION= <scene name='initialview01'>1oaq</scene>, resolution 1.50&Aring;
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<StructureSection load='1oaq' size='340' side='right'caption='[[1oaq]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND=
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<table><tr><td colspan='2'>[[1oaq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OAQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1OAQ FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
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|GENE=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1oaq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1oaq OCA], [https://pdbe.org/1oaq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1oaq RCSB], [https://www.ebi.ac.uk/pdbsum/1oaq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1oaq ProSAT]</span></td></tr>
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|DOMAIN=
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</table>
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|RELATEDENTRY=
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== Function ==
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1oaq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1oaq OCA], [http://www.ebi.ac.uk/pdbsum/1oaq PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1oaq RCSB]</span>
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[https://www.uniprot.org/uniprot/LV1B_MOUSE LV1B_MOUSE]
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}}
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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'''FREE CONFORMATION AB1 OF THE IGE SPE-7'''
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/oa/1oaq_consurf.spt"</scriptWhenChecked>
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==Overview==
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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A single antibody was shown to adopt different binding-site conformations and thereby bind unrelated antigens. Analysis by both x-ray crystallography and pre-steady-state kinetics revealed an equilibrium between different preexisting isomers, one of which possessed a promiscuous, low-affinity binding site for aromatic ligands, including the immunizing hapten. A subsequent induced-fit isomerization led to high-affinity complexes with a deep and narrow binding site. A protein antigen identified by repertoire selection made use of an unrelated antibody isomer with a wide, shallow binding site. Conformational diversity, whereby one sequence adopts multiple structures and multiple functions, can increase the effective size of the antibody repertoire but may also lead to autoimmunity and allergy.
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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==About this Structure==
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1oaq ConSurf].
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1OAQ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_rattus Rattus rattus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OAQ OCA].
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<div style="clear:both"></div>
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__TOC__
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==Reference==
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</StructureSection>
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Antibody multispecificity mediated by conformational diversity., James LC, Roversi P, Tawfik DS, Science. 2003 Feb 28;299(5611):1362-7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12610298 12610298]
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[[Category: Large Structures]]
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[[Category: Rattus rattus]]
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[[Category: Mus musculus]]
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[[Category: Single protein]]
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[[Category: James LC]]
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[[Category: James, L C.]]
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[[Category: Roversi P]]
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[[Category: Roversi, P.]]
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[[Category: Tawfik D]]
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[[Category: Tawfik, D.]]
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[[Category: allergy]]
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[[Category: antibody]]
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[[Category: conformational diversity]]
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[[Category: ige]]
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[[Category: multispecificity]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:42:27 2008''
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Current revision

Free conformation Ab1 of the IgE SPE-7

PDB ID 1oaq

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