Selectin
From Proteopedia
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| - | <StructureSection load='1g1r' size=' | + | <StructureSection load='1g1r' size='350' side='right' caption='Structure of P-selectin EGF domain complex with tetrasaccharide and Ca+2 ion (green) (PDB entry [[1g1r]])' scene='55/552185/Cv/1'> |
== Function == | == Function == | ||
'''Selectin''' or '''CD62''' are cell adhesion molecules which bind sugar moieties and thus are regarded as lectins. The structure of selectin consists of extracellular calcium-dependent lectin domain, an EGF-like domain and a number of concensus repeat units, a transmembranal domain and a intracellular domain<ref>PMID:7542213</ref>. Three types of selectins are found:<br /> | '''Selectin''' or '''CD62''' are cell adhesion molecules which bind sugar moieties and thus are regarded as lectins. The structure of selectin consists of extracellular calcium-dependent lectin domain, an EGF-like domain and a number of concensus repeat units, a transmembranal domain and a intracellular domain<ref>PMID:7542213</ref>. Three types of selectins are found:<br /> | ||
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== Structural insight == | == Structural insight == | ||
| - | The <scene name='55/552185/Cv/ | + | The <scene name='55/552185/Cv/4'>tetrasaccharide binding interactions to P-selectin are electrostatic</scene><ref>PMID:11081633</ref>. <scene name='55/552185/Cv/5'>Ca coordination site</scene>. |
</StructureSection> | </StructureSection> | ||
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**[[3cfw]] – hCD62L EGF domain <br /> | **[[3cfw]] – hCD62L EGF domain <br /> | ||
| + | **[[5vc1]] – hCD62L EGF domain (mutant)<br /> | ||
**[[2lgf]] – hCD62L calmodulin-binding domain + calmodulin<br /> | **[[2lgf]] – hCD62L calmodulin-binding domain + calmodulin<br /> | ||
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**[[1g1t]] – hCD62E EGF domain + tetrasaccharide<br /> | **[[1g1t]] – hCD62E EGF domain + tetrasaccharide<br /> | ||
**[[4c16]] – hCD62 EGF+SCR domains + antagonist <br /> | **[[4c16]] – hCD62 EGF+SCR domains + antagonist <br /> | ||
| - | **[[4csy]] | + | **[[4csy]], [[6eyi]], [[6eyj]], [[6eyk]] - hCD62 EGF+SCR domains + ligand <br /> |
}} | }} | ||
Current revision
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3D structures of selectin
Updated on 21-January-2020
References
- ↑ Tedder TF, Steeber DA, Chen A, Engel P. The selectins: vascular adhesion molecules. FASEB J. 1995 Jul;9(10):866-73. PMID:7542213
- ↑ Ley K. The role of selectins in inflammation and disease. Trends Mol Med. 2003 Jun;9(6):263-8. PMID:12829015
- ↑ Szepietowski J, Wasik F, Bielicka E, Nockowski P, Noworolska A. Soluble E-selectin serum levels correlate with disease activity in psoriatic patients. Clin Exp Dermatol. 1999 Jan;24(1):33-6. PMID:10233646
- ↑ Kretowski A, Gillespie KM, Bingley PJ, Kinalska I. Soluble L-selectin levels in type I diabetes mellitus: a surrogate marker for disease activity? Immunology. 2000 Feb;99(2):320-5. PMID:10692053
- ↑ Somers WS, Tang J, Shaw GD, Camphausen RT. Insights into the molecular basis of leukocyte tethering and rolling revealed by structures of P- and E-selectin bound to SLe(X) and PSGL-1. Cell. 2000 Oct 27;103(3):467-79. PMID:11081633
