Talin
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| - | + | <StructureSection load='' size='350' side='right' scene='Talin/Cv/1' caption='Talin rod domain residues 1359-1659 (PDB code [[2x0c]])'> | |
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| + | [[Talin]] is involved in cell-cell contacts. It links integrins to actin<ref>PMID:19416068</ref>. It contains a C-terminal rod domain with integrin binding sites (IBS) and actin binding sites (ABS) and N-terminal FERM domain with subdomains F1-F3. The F3 subdomain interacts with integrin. Talin contains 3 [[Vinculin]] binding sites VBS1-VBS3. | ||
| + | </StructureSection> | ||
== 3D Structures of Talin == | == 3D Structures of Talin == | ||
| + | [[Talin 3D structures]] | ||
| - | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
| - | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
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| - | * Talin subdomains | ||
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| - | **[[2x0c]], [[2kbb]], [[3dyj]], [[1sj7]], [[1sj8]] – mTal rod – mouse<br /> | ||
| - | **[[2kma]] – mTal F0F1 – NMR<br /> | ||
| - | **[[2kc1]] - mTal F0 – NMR<br /> | ||
| - | **[[2kc2]] - mTal F1 – NMR<br /> | ||
| - | **[[2hrj]] - cTal F2 – NMR <br /> | ||
| - | **[[1mix]] – cTal F2F3<br /> | ||
| - | **[[4f7g]] - mTal F2F3 + rod segment domain<br /> | ||
| - | **[[2kgx]] – mTal F3+mTal fragment – NMR<br /> | ||
| - | **[[3ivf]] – mTal FERM domain<br /> | ||
| - | **[[2l7n]] – mTal B – NMR<br /> | ||
| - | **[[2l10]] – mTal C - NMR<br /> | ||
| - | **[[2lqg]] - mTal R4 helix – NMR<br /> | ||
| - | **[[4w8p]] - mTal R7-8 + RIAM <br /> | ||
| - | **[[2mwn]] – hTal1 + RIAM – human - NMR<br /> | ||
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| - | * Talin integrin-binding sites | ||
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| - | **[[2jsw]], [[2qdq]] – mTal IBS – NMR<br /> | ||
| - | **[[3g9w]] – mTal2 F2F3+integrin tail<br /> | ||
| - | **[[1miz]], [[1mk7]], [[1mk9]] - hTal+integrin tail<br /> | ||
| - | **[[2h7d]], [[2h7e]] - cTal FERM F3+integrlin fragment – NMR <br /> | ||
| - | **[[3fyq]] – Tal rod IBS2 – ''Drosophila melanogaster'' | ||
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| - | * Talin vinculin-binding sites | ||
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| - | **[[2kvp]], [[2b0h]] – mTal VBS3 – NMR<br /> | ||
| - | **[[1xwj]], [[1zvz]], [[1zw2]], [[1zw3]] - cTal VBS3+ vinculin head – chicken<br /> | ||
| - | **[[1u6h]] - cTal VBS2+ vinculin head<br /> | ||
| - | **[[1t01]] - cTal VBS1+ vinculin head<br /> | ||
| - | **[[1syq]] - hTal VBS1+ vinculin head <br /> | ||
| - | **[[1rkc]], [[3s90]] - hTal VBS3+ vinculin head<br /> | ||
| - | **[[1u89]], [[2l7a]] - mTal VBS2 – NMR<br /> | ||
| - | **[[4dj9]] – hTal VBS50 + vinculin head | ||
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| - | *Talin phosphatidylinositol phosphate kinase binding sites | ||
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| - | **[[1y19]] - mTal F2F3+ PIP kinase C-terminal<br /> | ||
| - | **[[2g35]] - mTal F3+PIP kinase peptide – NMR | ||
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| - | *Talin layilin-binding sites | ||
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| - | **[[2k00]] - cTal F3+layilin fragment – NMR | ||
| - | }} | ||
== References == | == References == | ||
<references/> | <references/> | ||
| + | </StructureSection> | ||
[[Category: Topic Page]] | [[Category: Topic Page]] | ||
Current revision
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3D Structures of Talin
References
- ↑ Critchley DR. Biochemical and structural properties of the integrin-associated cytoskeletal protein talin. Annu Rev Biophys. 2009;38:235-54. doi: 10.1146/annurev.biophys.050708.133744. PMID:19416068 doi:http://dx.doi.org/10.1146/annurev.biophys.050708.133744
</StructureSection>
