TATA-Binding Protein

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<scene name='TATA-Binding_Protein/Symmetrical/5'>two symmetrical halves</scene>.
<scene name='TATA-Binding_Protein/Symmetrical/5'>two symmetrical halves</scene>.
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The interactions of TBP with the DNA TATA box occurs with the minor groove of the DNA. The DNA duplex is bent in a sharp angle and most interactions are non-polar of hydrophobic<ref>PMID:8757291</ref>.
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The interactions of <scene name='10/100866/Cv/2'>TBP with the DNA TATA box occurs with the minor groove of the DNA</scene>. The DNA duplex is bent in a sharp angle and most interactions are non-polar of hydrophobic<ref>PMID:8757291</ref>.
{{Clear}}
{{Clear}}
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</StructureSection>
 
== 3D Structures of TATA-binding protein ==
== 3D Structures of TATA-binding protein ==
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[[TATA-binding protein 3D structures]]
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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</StructureSection>
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{{#tree:id=OrganizedByTopic|openlevels=0|
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* TBP
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**[[2z8u]] – TBP – ''Methanococcus janaschii''<br />
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**[[1pcz]] – PwTBP - ''Pyrococcus woesei''<br />
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**[[1vok]] – AtTBP - ''Arabidopsis thaliana''<br />
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**[[1tbp]] – yTBP - yeast<br />
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**[[4b04]] – yTBP (mutant)<br />
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**[[1mp9]] – TBP – ''Sulfolobus acidocaldarius''<br />
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**[[3eik]] – TBP – ''Encephalitozoon cuniculi''
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* TBP+DNA TATA box
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**[[1ytb]] - yTBP + DNA TATA<br />
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**[[1cdw]] - hTBP core domain+ DNA TATA - human<br />
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**[[1tgh]] - hTBP + DNA TATA<br />
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**[[1qn5]], [[1qn6]], [[1qn7]], [[1qn8]], [[1qn9]], [[1qna]], [[1qnb]], [[1qnc]], [[1qne]], [[1qn3]], [[1qn4]], [[1vto]] - AtTBP + DNA TATA <br />
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* TBP+DNA TATA box +TFIIA
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**[[1rm1]] – yTBP+TFIIA α, β, γ chains+ DNA TATA <br />
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**[[1ytf]] - yTBP+TFIIA + DNA TATA<br />
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**[[1nh2]] – yTBP C-terminal+TFIIA α, β, γ chains+ DNA TATA<br />
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**[[1nvp]] - hTBP C-terminal+ TFIIA α, β, γ chains+ DNA TATA <br />
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**[[1jfi]] - hTBP C-terminal+ TFIIA NC2+ DNA TATA<br />
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* TBP+DNA TATA box +TFIIB
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**[[1tba]] – yTBP core domain+TAFII230 fragment - NMR<br />
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**[[1c9b]] - hTBP C-terminal+TFIIBC+adenovirus major late promoter<br />
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**[[1vol]] – AtTBP+hTFIIB+DNA TATA<br />
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**[[1ais]], [[1d3u]] - PwTBP N-terminal+ TFIIB C-terminal + DNA TATA <br />
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**[[1tba]] – yTBP core domain+TAFII230 fragment - NMR<br />
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* TBP+DNA TATA+TFIIIB
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**[[1ngm]] - yTBP C-terminal+TFIIIB BRF1 subunit + DNA TATA<br />
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**[[4roc]], [[4rod]], [[4roe]] - hTBP +TFIIIB + DNA TATA<br />
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* TBP+DNA TATA+TFIIA+TFIID
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**[[5fur]] - yTBP +TFIIB + TFIID + DNA TATA<br />
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* TBP in RNA polymerase II complex
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**[[5fyw]], [[5fz5]], [[5fmf]], [[4v1n]], [[4v1o]] – yTBP + DNA-directed RNA polymerase II + TFII + DNA<br />
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**[[5iy6]], [[5iy7]], [[5iy8]], [[5iy9]], [[5iya]], [[5iyb]], [[5iyc]], [[5iyd]] – hTBP + DNA-directed RNA polymerase II + TFII + DNA<br />
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}}
 
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

Human TATA-binding protein complex with DNA TATA box (PDB code 1tgh)

Drag the structure with the mouse to rotate

References

  1. ↑ Caporaso N. Genetic susceptibility in the occupational setting: introduction to the workshop. Med Lav. 1995 May-Jun;86(3):199-206. PMID:7565278
  2. ↑ van Roon-Mom WM, Reid SJ, Faull RL, Snell RG. TATA-binding protein in neurodegenerative disease. Neuroscience. 2005;133(4):863-72. PMID:15916858 doi:http://dx.doi.org/10.1016/j.neuroscience.2005.03.024
  3. ↑ Juo ZS, Chiu TK, Leiberman PM, Baikalov I, Berk AJ, Dickerson RE. How proteins recognize the TATA box. J Mol Biol. 1996 Aug 16;261(2):239-54. PMID:8757291 doi:10.1006/jmbi.1996.0456

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Ala Jelani, Michal Harel, Eran Hodis, Alexander Berchansky, David Canner

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