Tetherin
From Proteopedia
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| + | <StructureSection load='2xg7' size='350' side='right' scene='' caption='Glycosylated human tetherin ectodomain dimer [[2xg7]]'> | ||
==Tetherin is a membrane-associated protein that may prevent the release of enveloped viruses from their host cells== | ==Tetherin is a membrane-associated protein that may prevent the release of enveloped viruses from their host cells== | ||
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| - | '''Tetherin''' has been shown to prevent the release of HIV-1 virions and may be an effective inhibitor of other enveloped viruses as well such as Lassa and Marburg viruses. Tetherin inhibits the release of virions by binding to viral particles budding from the cell membrane, preventing the release of these infectious particles. | + | '''Tetherin''' or '''bone marrow stromal antigen 2''' (BST-2) has been shown to prevent the release of HIV-1 virions and may be an effective inhibitor of other enveloped viruses as well such as Lassa and Marburg viruses. Tetherin inhibits the release of virions by binding to viral particles budding from the cell membrane, preventing the release of these infectious particles. |
The tetherin protein is always found on the surface of B lymphocytes, dendritic cells, and activated T lymphocytes. In brain, kidney, liver, skeletal muscle, pancreas and heart cells. The tetherin gene can be stimulated to be expressed by the production of alpha Interferon, a cytokine. | The tetherin protein is always found on the surface of B lymphocytes, dendritic cells, and activated T lymphocytes. In brain, kidney, liver, skeletal muscle, pancreas and heart cells. The tetherin gene can be stimulated to be expressed by the production of alpha Interferon, a cytokine. | ||
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*[[Viral Infections]] | *[[Viral Infections]] | ||
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| - | + | </StructureSection> | |
==3D structures of tetherin== | ==3D structures of tetherin== | ||
| + | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
| - | [[2x7a]], [[3nwh]], [[2xg7]], [[3mqb]] – | + | [[2x7a]], [[3nwh]], [[2xg7]], [[3mqb]], [[3mqc]] – hBST-2 ectodomain – human<br /> |
| - | [[3mq7]] - | + | [[3mq7]], [[3mq9]] - hBST-2 ectodomain (mutant)<br /> |
| + | [[2lk9]] – hBST-2 transmembrane (mutant) – NMR<br /> | ||
| + | [[4p6z]] – hBST-2 in adaptor protein complex<br /> | ||
| + | [[6cm9]], [[6owt]], [[6cri]], [[6d83]], [[6d84]], [[6dff]] – hBST-2/Nef in adaptor protein complex – Cryo EM<br /> | ||
| + | [[3ni0]] - BST-2 ectodomain – mouse<br /> | ||
Current revision
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3D structures of tetherin
Updated on 23-November-2020
2x7a, 3nwh, 2xg7, 3mqb, 3mqc – hBST-2 ectodomain – human
3mq7, 3mq9 - hBST-2 ectodomain (mutant)
2lk9 – hBST-2 transmembrane (mutant) – NMR
4p6z – hBST-2 in adaptor protein complex
6cm9, 6owt, 6cri, 6d83, 6d84, 6dff – hBST-2/Nef in adaptor protein complex – Cryo EM
3ni0 - BST-2 ectodomain – mouse
References
Sakuma, Noda, Urata, Kawaoka, & Yasuda (2009). Inhibition of Lassa and Marburg Virus Production by Tetherin. Journal of Virology. 83:2382-2385.
Neil, Zang, & Beiniasz (2008). Tetherin inhibits retroviral release and is antagonized by HIV-1 Vpu. Nature. 451: 425-430.
