5l8o

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==crystal structure of human FABP6 in complex with cholate==
==crystal structure of human FABP6 in complex with cholate==
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<StructureSection load='5l8o' size='340' side='right' caption='[[5l8o]], [[Resolution|resolution]] 2.39&Aring;' scene=''>
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<StructureSection load='5l8o' size='340' side='right'caption='[[5l8o]], [[Resolution|resolution]] 2.39&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5l8o]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5L8O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5L8O FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5l8o]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5L8O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5L8O FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CHD:CHOLIC+ACID'>CHD</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.39&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5l8o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5l8o OCA], [http://pdbe.org/5l8o PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5l8o RCSB], [http://www.ebi.ac.uk/pdbsum/5l8o PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5l8o ProSAT]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CHD:CHOLIC+ACID'>CHD</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5l8o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5l8o OCA], [https://pdbe.org/5l8o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5l8o RCSB], [https://www.ebi.ac.uk/pdbsum/5l8o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5l8o ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/FABP6_HUMAN FABP6_HUMAN]] Ileal protein which stimulates gastric acid and pepsinogen secretion. Seems to be able to bind to bile salts and bilirubins. Isoform 2 is essential for the survival of colon cancer cells to bile acid-induced apoptosis.<ref>PMID:17909007</ref>
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[https://www.uniprot.org/uniprot/FABP6_HUMAN FABP6_HUMAN] Ileal protein which stimulates gastric acid and pepsinogen secretion. Seems to be able to bind to bile salts and bilirubins. Isoform 2 is essential for the survival of colon cancer cells to bile acid-induced apoptosis.<ref>PMID:17909007</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5l8o" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5l8o" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Fatty acid-binding protein 3D structures|Fatty acid-binding protein 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Davenport, R]]
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[[Category: Homo sapiens]]
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[[Category: Hendrick, A]]
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[[Category: Large Structures]]
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[[Category: Leonard, P M]]
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[[Category: Davenport R]]
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[[Category: Mitchell, P]]
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[[Category: Hendrick A]]
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[[Category: Mueller, I]]
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[[Category: Leonard PM]]
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[[Category: Cholate]]
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[[Category: Mitchell P]]
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[[Category: Fabp6]]
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[[Category: Mueller I]]
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[[Category: Fatty acid binding protein 6]]
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[[Category: Fragment]]
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[[Category: Gastrotropin]]
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[[Category: I-babp]]
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[[Category: Ileal]]
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[[Category: Ileal bile acid binding protein]]
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[[Category: Lipid binding protein]]
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Current revision

crystal structure of human FABP6 in complex with cholate

PDB ID 5l8o

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