5jne

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==E2-SUMO-Siz1 E3-SUMO-PCNA complex==
==E2-SUMO-Siz1 E3-SUMO-PCNA complex==
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<StructureSection load='5jne' size='340' side='right' caption='[[5jne]], [[Resolution|resolution]] 2.85&Aring;' scene=''>
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<StructureSection load='5jne' size='340' side='right'caption='[[5jne]], [[Resolution|resolution]] 2.85&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5jne]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JNE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5JNE FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5jne]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JNE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5JNE FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6LN:ETHANE-1,2-DITHIOL'>6LN</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.85&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5jne FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jne OCA], [http://pdbe.org/5jne PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5jne RCSB], [http://www.ebi.ac.uk/pdbsum/5jne PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5jne ProSAT]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6LN:ETHANE-1,2-DITHIOL'>6LN</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5jne FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jne OCA], [https://pdbe.org/5jne PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5jne RCSB], [https://www.ebi.ac.uk/pdbsum/5jne PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5jne ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/PCNA_YEAST PCNA_YEAST]] This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. Involved in DNA repair.<ref>PMID:11545742</ref> <ref>PMID:12226657</ref> [[http://www.uniprot.org/uniprot/SIZ1_YEAST SIZ1_YEAST]] Acts as an E3 ligase mediating SUMO/Smt3 attachment to septins and PCNA. May be involved in chromosome maintenance.<ref>PMID:11572779</ref> <ref>PMID:11587849</ref> <ref>PMID:11333221</ref> <ref>PMID:11577116</ref> <ref>PMID:12226657</ref> [[http://www.uniprot.org/uniprot/SMT3_YEAST SMT3_YEAST]] Not known; suppressor of MIF2 mutations. [[http://www.uniprot.org/uniprot/UBC9_YEAST UBC9_YEAST]] E2 ubiquitin-like--protein ligase mediating SUMO/Smt3 attachment to septins and PCNA. Seems to be involved in degradation of S- (CLB5) and M-phase cyclins (CLB2).<ref>PMID:9341106</ref> <ref>PMID:11572779</ref>
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[https://www.uniprot.org/uniprot/UBC9_YEAST UBC9_YEAST] E2 ubiquitin-like--protein ligase mediating SUMO/Smt3 attachment to septins and PCNA. Seems to be involved in degradation of S- (CLB5) and M-phase cyclins (CLB2).<ref>PMID:9341106</ref> <ref>PMID:11572779</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
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*[[Proliferating cell nuclear antigen 3D structures|Proliferating cell nuclear antigen 3D structures]]
*[[SUMO conjugating enzyme Ubc9|SUMO conjugating enzyme Ubc9]]
*[[SUMO conjugating enzyme Ubc9|SUMO conjugating enzyme Ubc9]]
== References ==
== References ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Lima, C D]]
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[[Category: Large Structures]]
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[[Category: Streich, F C]]
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[[Category: Saccharomyces cerevisiae S288C]]
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[[Category: E2 conjugating enzyme]]
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[[Category: Lima CD]]
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[[Category: E3 ligase]]
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[[Category: Streich Jr FC]]
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[[Category: Ligase-signaling protein complex]]
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[[Category: Substrate complex]]
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[[Category: Sumo]]
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[[Category: Ubiquitin]]
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[[Category: Ubiquitin-like]]
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Current revision

E2-SUMO-Siz1 E3-SUMO-PCNA complex

PDB ID 5jne

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