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5kuk

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==Crystal Structure of Inward Rectifier Kir2.2 K62W Mutant==
==Crystal Structure of Inward Rectifier Kir2.2 K62W Mutant==
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<StructureSection load='5kuk' size='340' side='right' caption='[[5kuk]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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<StructureSection load='5kuk' size='340' side='right'caption='[[5kuk]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5kuk]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KUK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5KUK FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5kuk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KUK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5KUK FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DMU:DECYL-BETA-D-MALTOPYRANOSIDE'>DMU</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5kum|5kum]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DMU:DECYL-BETA-D-MALTOPYRANOSIDE'>DMU</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5kuk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5kuk OCA], [http://pdbe.org/5kuk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5kuk RCSB], [http://www.ebi.ac.uk/pdbsum/5kuk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5kuk ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5kuk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5kuk OCA], [https://pdbe.org/5kuk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5kuk RCSB], [https://www.ebi.ac.uk/pdbsum/5kuk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5kuk ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/KCJ12_CHICK KCJ12_CHICK]] Inward rectifying potassium channel that is activated by phosphatidylinositol 4,5-bisphosphate and that probably participates in controlling the resting membrane potential in electrically excitable cells. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. The inward rectification is probably due to the blockage of outward current by cytoplasmic polyamines and/or magnesium ions.<ref>PMID:20019282</ref> <ref>PMID:21874019</ref>
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[https://www.uniprot.org/uniprot/KCJ12_CHICK KCJ12_CHICK] Inward rectifying potassium channel that is activated by phosphatidylinositol 4,5-bisphosphate and that probably participates in controlling the resting membrane potential in electrically excitable cells. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. The inward rectification is probably due to the blockage of outward current by cytoplasmic polyamines and/or magnesium ions.<ref>PMID:20019282</ref> <ref>PMID:21874019</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5kuk" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5kuk" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Potassium channel 3D structures|Potassium channel 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Heyman, S]]
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[[Category: Gallus gallus]]
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[[Category: Lee, S J]]
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[[Category: Large Structures]]
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[[Category: Nichols, C G]]
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[[Category: Heyman S]]
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[[Category: Ren, F]]
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[[Category: Lee S-J]]
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[[Category: Yuan, P]]
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[[Category: Nichols CG]]
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[[Category: Metal transport]]
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[[Category: Ren F]]
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[[Category: Metal transport kir 2 2 k62w mutant structure]]
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[[Category: Yuan P]]

Current revision

Crystal Structure of Inward Rectifier Kir2.2 K62W Mutant

PDB ID 5kuk

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