5i2e

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==Human Histidine Triad Nucleotide Binding Protein 1 (Hint1) with Bound Sulfamate Inhibitor 3a:3-(5-O-{[3-(1H-indol-3-yl)propanoyl]sulfamoyl}-beta-D-ribofuranosyl)-3H-imidazo[2,1-i]purine==
==Human Histidine Triad Nucleotide Binding Protein 1 (Hint1) with Bound Sulfamate Inhibitor 3a:3-(5-O-{[3-(1H-indol-3-yl)propanoyl]sulfamoyl}-beta-D-ribofuranosyl)-3H-imidazo[2,1-i]purine==
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<StructureSection load='5i2e' size='340' side='right' caption='[[5i2e]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
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<StructureSection load='5i2e' size='340' side='right'caption='[[5i2e]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5i2e]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5I2E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5I2E FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5i2e]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5I2E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5I2E FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=67D:3-(5-O-{[3-(1H-INDOL-3-YL)PROPANOYL]SULFAMOYL}-BETA-D-RIBOFURANOSYL)-3H-IMIDAZO[2,1-I]PURINE'>67D</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3tw2|3tw2]], [[4eqe|4eqe]], [[4eqg|4eqg]], [[4eqh|4eqh]], [[5i2f|5i2f]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=67D:3-(5-O-{[3-(1H-INDOL-3-YL)PROPANOYL]SULFAMOYL}-BETA-D-RIBOFURANOSYL)-3H-IMIDAZO[2,1-I]PURINE'>67D</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5i2e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5i2e OCA], [http://pdbe.org/5i2e PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5i2e RCSB], [http://www.ebi.ac.uk/pdbsum/5i2e PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5i2e ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5i2e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5i2e OCA], [https://pdbe.org/5i2e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5i2e RCSB], [https://www.ebi.ac.uk/pdbsum/5i2e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5i2e ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/HINT1_HUMAN HINT1_HUMAN]] Hydrolyzes adenosine 5'-monophosphoramidate substrates such as AMP-morpholidate, AMP-N-alanine methyl ester, AMP-alpha-acetyl lysine methyl ester and AMP-NH2 (By similarity).
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[https://www.uniprot.org/uniprot/HINT1_HUMAN HINT1_HUMAN] Hydrolyzes adenosine 5'-monophosphoramidate substrates such as AMP-morpholidate, AMP-N-alanine methyl ester, AMP-alpha-acetyl lysine methyl ester and AMP-NH2 (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5i2e" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5i2e" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Histidine triad nucleotide-binding protein 3D structures|Histidine triad nucleotide-binding protein 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Finzel, B C]]
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[[Category: Homo sapiens]]
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[[Category: Strom, A M]]
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[[Category: Large Structures]]
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[[Category: Wagner, C R]]
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[[Category: Finzel BC]]
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[[Category: Hint]]
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[[Category: Strom AM]]
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[[Category: Histidine triad]]
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[[Category: Wagner CR]]
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[[Category: Hit]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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Current revision

Human Histidine Triad Nucleotide Binding Protein 1 (Hint1) with Bound Sulfamate Inhibitor 3a:3-(5-O-{[3-(1H-indol-3-yl)propanoyl]sulfamoyl}-beta-D-ribofuranosyl)-3H-imidazo[2,1-i]purine

PDB ID 5i2e

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OCA

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