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5hzr

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==Crystal structure of MtSnf2==
==Crystal structure of MtSnf2==
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<StructureSection load='5hzr' size='340' side='right' caption='[[5hzr]], [[Resolution|resolution]] 2.33&Aring;' scene=''>
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<StructureSection load='5hzr' size='340' side='right'caption='[[5hzr]], [[Resolution|resolution]] 2.33&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5hzr]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HZR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5HZR FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5hzr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermothelomyces_thermophilus_ATCC_42464 Thermothelomyces thermophilus ATCC 42464]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HZR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5HZR FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=KH2:3-(1-METHYLPIPERIDINIUM-1-YL)PROPANE-1-SULFONATE'>KH2</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.33&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5hzr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hzr OCA], [http://pdbe.org/5hzr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5hzr RCSB], [http://www.ebi.ac.uk/pdbsum/5hzr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5hzr ProSAT]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=KH2:3-(1-METHYLPIPERIDINIUM-1-YL)PROPANE-1-SULFONATE'>KH2</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5hzr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hzr OCA], [https://pdbe.org/5hzr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5hzr RCSB], [https://www.ebi.ac.uk/pdbsum/5hzr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5hzr ProSAT]</span></td></tr>
</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/G2QDW1_MYCTT G2QDW1_MYCTT]
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SWI2/SNF2 family proteins regulate a myriad of nucleic acid transactions by sliding, removing and reconstructing nucleosomes in eukaryotic cells. They contain two RecA-like core domains, which couple ATP hydrolysis and DNA translocation to chromatin remodeling. Here we report the crystal structure of Snf2 from the yeast Myceliophthora thermophila. The data show the two RecA-like core domains of Snf2 stacking together and twisting their ATP-binding motifs away from each other, thus explaining the inactivity of the protein in the ground state. We identified several DNA-binding elements, which are fully exposed to solvent, thus suggesting that the protein is poised for its incoming substrate. The catalytic core of Snf2 showed a high chromatin-remodeling activity, which was suppressed by the N-terminal HSA domain. Our findings reveal that the catalytic core of Snf2 is a competent remodeling machine, which rests in an inactive conformation and requires a large conformational change upon activation.
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Structure of chromatin remodeler Swi2/Snf2 in the resting state.,Xia X, Liu X, Li T, Fang X, Chen Z Nat Struct Mol Biol. 2016 Aug;23(8):722-9. doi: 10.1038/nsmb.3259. Epub 2016 Jul , 11. PMID:27399259<ref>PMID:27399259</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 5hzr" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Chen, Z C]]
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[[Category: Large Structures]]
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[[Category: Xia, X]]
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[[Category: Thermothelomyces thermophilus ATCC 42464]]
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[[Category: Chromatin remodeling]]
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[[Category: Chen ZC]]
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[[Category: Swi2/snf2]]
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[[Category: Xia X]]
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[[Category: Transcription]]
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Current revision

Crystal structure of MtSnf2

PDB ID 5hzr

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