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5fjv

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==Crystal structure of the extracellular domain of alpha2 nicotinic acetylcholine receptor in pentameric assembly==
==Crystal structure of the extracellular domain of alpha2 nicotinic acetylcholine receptor in pentameric assembly==
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<StructureSection load='5fjv' size='340' side='right' caption='[[5fjv]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
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<StructureSection load='5fjv' size='340' side='right'caption='[[5fjv]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5fjv]] is a 5 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FJV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5FJV FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5fjv]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FJV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5FJV FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EPJ:EPIBATIDINE'>EPJ</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.2&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5fjv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fjv OCA], [http://pdbe.org/5fjv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fjv RCSB], [http://www.ebi.ac.uk/pdbsum/5fjv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5fjv ProSAT]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EPJ:EPIBATIDINE'>EPJ</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5fjv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fjv OCA], [https://pdbe.org/5fjv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5fjv RCSB], [https://www.ebi.ac.uk/pdbsum/5fjv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5fjv ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
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[[http://www.uniprot.org/uniprot/ACHA2_HUMAN ACHA2_HUMAN]] Autosomal dominant nocturnal frontal lobe epilepsy. The disease is caused by mutations affecting the gene represented in this entry.
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[https://www.uniprot.org/uniprot/ACHA2_HUMAN ACHA2_HUMAN] Autosomal dominant nocturnal frontal lobe epilepsy. The disease is caused by mutations affecting the gene represented in this entry.
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/ACHA2_HUMAN ACHA2_HUMAN]] After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
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[https://www.uniprot.org/uniprot/ACHA2_HUMAN ACHA2_HUMAN] After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5fjv" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5fjv" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Acetyl choline receptor 3D structures|Acetyl choline receptor 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Chroni-Tzartou, D]]
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[[Category: Homo sapiens]]
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[[Category: Giastas, P]]
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[[Category: Large Structures]]
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[[Category: Kouvatsos, N]]
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[[Category: Chroni-Tzartou D]]
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[[Category: Tzartos, S J]]
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[[Category: Giastas P]]
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[[Category: Acetylcholine-binding protein]]
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[[Category: Kouvatsos N]]
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[[Category: Agonist]]
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[[Category: Tzartos SJ]]
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[[Category: Alpha2]]
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[[Category: Epibatidine]]
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[[Category: Extracellular domain]]
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[[Category: Nachr]]
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[[Category: Nicotinic acetylcholine receptor]]
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Current revision

Crystal structure of the extracellular domain of alpha2 nicotinic acetylcholine receptor in pentameric assembly

PDB ID 5fjv

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