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5dsx

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==Crystal structure of Dot1L in complex with inhibitor CPD10 [6'-chloro-1,4-dimethyl-5'-(2-methyl-6-((4-(methylamino)pyrimidin-2-yl)amino)-1H-indol-1-yl)-[3,3'-bipyridin]-2(1H)-one]==
==Crystal structure of Dot1L in complex with inhibitor CPD10 [6'-chloro-1,4-dimethyl-5'-(2-methyl-6-((4-(methylamino)pyrimidin-2-yl)amino)-1H-indol-1-yl)-[3,3'-bipyridin]-2(1H)-one]==
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<StructureSection load='5dsx' size='340' side='right' caption='[[5dsx]], [[Resolution|resolution]] 2.41&Aring;' scene=''>
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<StructureSection load='5dsx' size='340' side='right'caption='[[5dsx]], [[Resolution|resolution]] 2.41&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5dsx]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DSX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5DSX FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5dsx]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DSX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5DSX FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5EW:6-CHLORO-1,4-DIMETHYL-5-(2-METHYL-6-{[4-(METHYLAMINO)PYRIMIDIN-2-YL]AMINO}-1H-INDOL-1-YL)-3,3-BIPYRIDIN-2(1H)-ONE'>5EW</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.41&#8491;</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Histone-lysine_N-methyltransferase Histone-lysine N-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.43 2.1.1.43] </span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5EW:6-CHLORO-1,4-DIMETHYL-5-(2-METHYL-6-{[4-(METHYLAMINO)PYRIMIDIN-2-YL]AMINO}-1H-INDOL-1-YL)-3,3-BIPYRIDIN-2(1H)-ONE'>5EW</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5dsx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5dsx OCA], [http://pdbe.org/5dsx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5dsx RCSB], [http://www.ebi.ac.uk/pdbsum/5dsx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5dsx ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5dsx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5dsx OCA], [https://pdbe.org/5dsx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5dsx RCSB], [https://www.ebi.ac.uk/pdbsum/5dsx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5dsx ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/DOT1L_HUMAN DOT1L_HUMAN]] Histone methyltransferase. Methylates 'Lys-79' of histone H3. Nucleosomes are preferred as substrate compared to free histones. Binds to DNA.
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[https://www.uniprot.org/uniprot/DOT1L_HUMAN DOT1L_HUMAN] Histone methyltransferase. Methylates 'Lys-79' of histone H3. Nucleosomes are preferred as substrate compared to free histones. Binds to DNA.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5dsx" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5dsx" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Histone methyltransferase 3D structures|Histone methyltransferase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Histone-lysine N-methyltransferase]]
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[[Category: Homo sapiens]]
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[[Category: Be, C]]
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[[Category: Large Structures]]
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[[Category: Gaul, C]]
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[[Category: Be C]]
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[[Category: Moebitz, H]]
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[[Category: Gaul C]]
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[[Category: Scheufler, C]]
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[[Category: Moebitz H]]
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[[Category: Complex]]
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[[Category: Scheufler C]]
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[[Category: Inhibitor]]
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[[Category: Transferase]]
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Current revision

Crystal structure of Dot1L in complex with inhibitor CPD10 [6'-chloro-1,4-dimethyl-5'-(2-methyl-6-((4-(methylamino)pyrimidin-2-yl)amino)-1H-indol-1-yl)-[3,3'-bipyridin]-2(1H)-one]

PDB ID 5dsx

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