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5jj2

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==Crystal structure of the central domain of human AKAP18 gamma/delta in complex with malonate==
==Crystal structure of the central domain of human AKAP18 gamma/delta in complex with malonate==
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<StructureSection load='5jj2' size='340' side='right' caption='[[5jj2]], [[Resolution|resolution]] 1.25&Aring;' scene=''>
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<StructureSection load='5jj2' size='340' side='right'caption='[[5jj2]], [[Resolution|resolution]] 1.25&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5jj2]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JJ2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5JJ2 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5jj2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JJ2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5JJ2 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MLI:MALONATE+ION'>MLI</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.25&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5jj2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jj2 OCA], [http://pdbe.org/5jj2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5jj2 RCSB], [http://www.ebi.ac.uk/pdbsum/5jj2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5jj2 ProSAT]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MLI:MALONATE+ION'>MLI</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5jj2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jj2 OCA], [https://pdbe.org/5jj2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5jj2 RCSB], [https://www.ebi.ac.uk/pdbsum/5jj2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5jj2 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/AKA7G_HUMAN AKA7G_HUMAN]] Probably targets cAMP-dependent protein kinase (PKA) to the cellular membrane or cytoskeletal structures. The membrane-associated form reduces epithelial sodium channel (ENaC) activity, whereas the free cytoplasmic form may negatively regulate ENaC channel feedback inhibition by intracellular sodium.<ref>PMID:10613906</ref> <ref>PMID:17244820</ref>
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[https://www.uniprot.org/uniprot/AKA7G_HUMAN AKA7G_HUMAN] Probably targets cAMP-dependent protein kinase (PKA) to the cellular membrane or cytoskeletal structures. The membrane-associated form reduces epithelial sodium channel (ENaC) activity, whereas the free cytoplasmic form may negatively regulate ENaC channel feedback inhibition by intracellular sodium.<ref>PMID:10613906</ref> <ref>PMID:17244820</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5jj2" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5jj2" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[A-kinase anchor protein 3D structures|A-kinase anchor protein 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Bjerregaard-Andersen, K]]
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[[Category: Homo sapiens]]
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[[Category: Morth, J P]]
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[[Category: Large Structures]]
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[[Category: Ostensen, E]]
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[[Category: Bjerregaard-Andersen K]]
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[[Category: Scott, J D]]
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[[Category: Morth JP]]
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[[Category: Tasken, K]]
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[[Category: Ostensen E]]
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[[Category: A-kinase anchoring]]
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[[Category: Scott JD]]
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[[Category: Akap]]
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[[Category: Tasken K]]
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[[Category: Central domain]]
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[[Category: Complex]]
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[[Category: Hydrolase]]
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[[Category: Malonate]]
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[[Category: Phospoesterase]]
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Current revision

Crystal structure of the central domain of human AKAP18 gamma/delta in complex with malonate

PDB ID 5jj2

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