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5grj

From Proteopedia

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m (Protected "5grj" [edit=sysop:move=sysop])
Current revision (11:40, 2 August 2023) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 5grj is ON HOLD
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==Crystal structure of human PD-L1 with monoclonal antibody avelumab==
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<StructureSection load='5grj' size='340' side='right'caption='[[5grj]], [[Resolution|resolution]] 3.21&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5grj]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5GRJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5GRJ FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.206&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5grj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5grj OCA], [https://pdbe.org/5grj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5grj RCSB], [https://www.ebi.ac.uk/pdbsum/5grj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5grj ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PD1L1_HUMAN PD1L1_HUMAN] Involved in the costimulatory signal, essential for T-cell proliferation and production of IL10 and IFNG, in an IL2-dependent and a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation and cytokine production.<ref>PMID:10581077</ref> <ref>PMID:11015443</ref>
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Authors: Liu, K., Tan, S., Chai, Y., Chen, D., Song, H., Zhang, C.W.-H., Shi, Y., Liu, J., Tan, W., Lyu, J., Gao, S., Yan, J., Qi, J., Gao, G.F.
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==See Also==
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*[[Monoclonal Antibodies 3D structures|Monoclonal Antibodies 3D structures]]
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Description: Crystal structure of human PD-L1 with monoclonal antibody avelumab
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== References ==
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[[Category: Unreleased Structures]]
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<references/>
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[[Category: Tan, S]]
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__TOC__
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[[Category: Gao, G.F]]
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</StructureSection>
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[[Category: Tan, W]]
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[[Category: Homo sapiens]]
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[[Category: Liu, J]]
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[[Category: Large Structures]]
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[[Category: Song, H]]
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[[Category: Chai Y]]
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[[Category: Shi, Y]]
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[[Category: Chen D]]
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[[Category: Gao, S]]
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[[Category: Gao GF]]
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[[Category: Lyu, J]]
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[[Category: Gao S]]
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[[Category: Chai, Y]]
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[[Category: Liu J]]
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[[Category: Liu, K]]
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[[Category: Liu K]]
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[[Category: Chen, D]]
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[[Category: Lyu J]]
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[[Category: Yan, J]]
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[[Category: Qi J]]
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[[Category: Zhang, C.W.-H]]
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[[Category: Shi Y]]
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[[Category: Qi, J]]
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[[Category: Song H]]
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[[Category: Tan S]]
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[[Category: Tan W]]
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[[Category: Yan J]]
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[[Category: Zhang CW-H]]

Current revision

Crystal structure of human PD-L1 with monoclonal antibody avelumab

PDB ID 5grj

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OCA

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