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1ofo

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[[Image:1ofo.jpg|left|200px]]
 
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{{Structure
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==Crystal Structure of the Tyrosine Regulated 3-Deoxy-D-Arabino-Heptulosonate-7-Phosphate Synthase from Saccharomyces Cerevisiae in Complex with 2-Phosphoglycolate==
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|PDB= 1ofo |SIZE=350|CAPTION= <scene name='initialview01'>1ofo</scene>, resolution 1.86&Aring;
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<StructureSection load='1ofo' size='340' side='right'caption='[[1ofo]], [[Resolution|resolution]] 1.86&Aring;' scene=''>
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|SITE= <scene name='pdbsite=AC1:Pga+Binding+Site+For+Chain+B'>AC1</scene>
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=PGA:2-PHOSPHOGLYCOLIC+ACID'>PGA</scene>
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<table><tr><td colspan='2'>[[1ofo]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OFO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1OFO FirstGlance]. <br>
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/3-deoxy-7-phosphoheptulonate_synthase 3-deoxy-7-phosphoheptulonate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.54 2.5.1.54] </span>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.86&#8491;</td></tr>
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|GENE=
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PGA:2-PHOSPHOGLYCOLIC+ACID'>PGA</scene></td></tr>
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|DOMAIN=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ofo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ofo OCA], [https://pdbe.org/1ofo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ofo RCSB], [https://www.ebi.ac.uk/pdbsum/1ofo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ofo ProSAT]</span></td></tr>
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|RELATEDENTRY=
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</table>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ofo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ofo OCA], [http://www.ebi.ac.uk/pdbsum/1ofo PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1ofo RCSB]</span>
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== Function ==
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}}
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[https://www.uniprot.org/uniprot/AROG_YEAST AROG_YEAST] Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/of/1ofo_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ofo ConSurf].
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<div style="clear:both"></div>
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'''CRYSTAL STRUCTURE OF THE TYROSINE REGULATED 3-DEOXY-D-ARABINO-HEPTULOSONATE-7-PHOSPHATE SYNTHASE FROM SACCHAROMYCES CEREVISIAE IN COMPLEX WITH 2-PHOSPHOGLYCOLATE'''
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==See Also==
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*[[DAHP synthase 3D structures|DAHP synthase 3D structures]]
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__TOC__
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==About this Structure==
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</StructureSection>
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1OFO is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OFO OCA].
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[[Category: Large Structures]]
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[[Category: 3-deoxy-7-phosphoheptulonate synthase]]
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[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
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[[Category: Single protein]]
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[[Category: Braus G]]
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[[Category: Braus, G.]]
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[[Category: Heinrich G]]
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[[Category: Heinrich, G.]]
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[[Category: Koenig V]]
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[[Category: Koenig, V.]]
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[[Category: Pfeil A]]
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[[Category: Pfeil, A.]]
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[[Category: Schneider TR]]
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[[Category: Schneider, T R.]]
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[[Category: aldolase]]
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[[Category: aromatic amino-acid biosynthesis synthase]]
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[[Category: beta-alpha-barrel]]
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[[Category: lyase]]
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[[Category: manganese]]
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[[Category: synthetase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:44:38 2008''
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Current revision

Crystal Structure of the Tyrosine Regulated 3-Deoxy-D-Arabino-Heptulosonate-7-Phosphate Synthase from Saccharomyces Cerevisiae in Complex with 2-Phosphoglycolate

PDB ID 1ofo

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