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5gv2
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 5gv2 is ON HOLD Authors: Gai, Z.C., Wu, G Description: Crystal structure of Arginine-bound CASTOR1 from Homo sapiens [[Category: Unreleased Structu...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of Arginine-bound CASTOR1 from Homo sapiens== | |
| - | + | <StructureSection load='5gv2' size='340' side='right'caption='[[5gv2]], [[Resolution|resolution]] 2.06Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5gv2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5GV2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5GV2 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.06Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ARG:ARGININE'>ARG</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5gv2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5gv2 OCA], [https://pdbe.org/5gv2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5gv2 RCSB], [https://www.ebi.ac.uk/pdbsum/5gv2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5gv2 ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/CAST1_HUMAN CAST1_HUMAN] Functions as an intracellular arginine sensor within the amino acid-sensing branch of the TORC1 signaling pathway (PubMed:26972053, PubMed:27487210, PubMed:33594058). As a homodimer or a heterodimer with CASTOR2, binds and inhibits the GATOR subcomplex GATOR2 and thereby mTORC1 (PubMed:26972053, PubMed:27487210, PubMed:33594058). Binding of arginine to CASTOR1 allosterically disrupts the interaction of CASTOR1-containing dimers with GATOR2 which can in turn activate mTORC1 and the TORC1 signaling pathway (PubMed:26972053, PubMed:27487210, PubMed:33594058).<ref>PMID:26972053</ref> <ref>PMID:27487210</ref> <ref>PMID:33594058</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Gai ZC]] | ||
| + | [[Category: Wu G]] | ||
Current revision
Crystal structure of Arginine-bound CASTOR1 from Homo sapiens
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