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5t3d
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 5t3d is ON HOLD Authors: Miller, B.R., Drake, E.J., Sundlov, J.A., Gulick, A.M. Description: Crystal structure of holo-EntF a nonribosomal peptide ...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of holo-EntF a nonribosomal peptide synthetase in the thioester-forming conformation== | |
| - | + | <StructureSection load='5t3d' size='340' side='right'caption='[[5t3d]], [[Resolution|resolution]] 2.80Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5t3d]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4zxj 4zxj]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5T3D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5T3D FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=75C:5-({[(2R,3S)-3-AMINO-4-HYDROXY-2-{[2-({N-[(2R)-2-HYDROXY-3,3-DIMETHYL-4-(PHOSPHONOOXY)BUTANOYL]-BETA-ALANYL}AMINO)ETHYL]SULFANYL}BUTYL]SULFONYL}AMINO)-5-DEOXYADENOSINE'>75C</scene></td></tr> |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5t3d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5t3d OCA], [https://pdbe.org/5t3d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5t3d RCSB], [https://www.ebi.ac.uk/pdbsum/5t3d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5t3d ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| - | [[Category: Gulick | + | == Function == |
| - | [[Category: Miller | + | [https://www.uniprot.org/uniprot/ENTF_ECOLI ENTF_ECOLI] Activates the carboxylate group of L-serine via ATP-dependent PPi exchange reactions to the aminoacyladenylate, preparing that molecule for the final stages of enterobactin synthesis. Holo-EntF acts as the catalyst for the formation of the three amide and three ester bonds present in the cyclic (2,3-dihydroxybenzoyl)serine trimer enterobactin, using seryladenylate and acyl-holo-EntB (acylated with 2,3-dihydroxybenzoate by EntE). |
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Escherichia coli K-12]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Drake EJ]] | ||
| + | [[Category: Gulick AM]] | ||
| + | [[Category: Miller BR]] | ||
| + | [[Category: Sundlov JA]] | ||
Current revision
Crystal structure of holo-EntF a nonribosomal peptide synthetase in the thioester-forming conformation
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