This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
5t3p
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 5t3p is ON HOLD Authors: Srikannathasan, V., Nunez, C.A., Tallant, C., Kopec, J., Elkins, J., Burgess-Brown, N., Arrowsmith, C.H., Edwards, A.M., Bo...) |
|||
| (5 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of Human Peroxisomal coenzyme A diphosphatase NUDT7== | |
| - | + | <StructureSection load='5t3p' size='340' side='right'caption='[[5t3p]], [[Resolution|resolution]] 2.03Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5t3p]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5T3P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5T3P FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.03Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr> |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5t3p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5t3p OCA], [https://pdbe.org/5t3p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5t3p RCSB], [https://www.ebi.ac.uk/pdbsum/5t3p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5t3p ProSAT]</span></td></tr> |
| - | [[Category: Burgess-Brown | + | </table> |
| - | [[Category: | + | == Function == |
| - | [[Category: | + | [https://www.uniprot.org/uniprot/NUDT7_HUMAN NUDT7_HUMAN] Coenzyme A diphosphatase which mediates the cleavage of CoA, CoA esters and oxidized CoA with similar efficiencies, yielding 3',5'-ADP and the corresponding 4'-phosphopantetheine derivative as products. CoA into 3',5'-ADP and 4'-phosphopantetheine. Has no activity toward NDP-sugars, CDP-alcohols, (deoxy)nucleoside 5'-triphosphates, nucleoside 5'-di or monophosphates, diadenosine polyphosphates, NAD, NADH, NADP, NADPH or thymidine-5'-monophospho-p-nitrophenyl ester. May be required to eliminate oxidized CoA from peroxisomes, or regulate CoA and acyl-CoA levels in this organelle in response to metabolic demand. Does not play a role in U8 snoRNA decapping activity. Binds U8 snoRNA (By similarity). |
| - | [[Category: Huber | + | __TOC__ |
| - | [[Category: | + | </StructureSection> |
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Arrowsmith CH]] |
| - | [[Category: Tallant | + | [[Category: Bountra C]] |
| - | [[Category: | + | [[Category: Burgess-Brown N]] |
| + | [[Category: Edwards AM]] | ||
| + | [[Category: Elkins JM]] | ||
| + | [[Category: Huber K]] | ||
| + | [[Category: Kopec J]] | ||
| + | [[Category: Mathea S]] | ||
| + | [[Category: Nunez CA]] | ||
| + | [[Category: Siejka P]] | ||
| + | [[Category: Srikannathasan V]] | ||
| + | [[Category: Tallant C]] | ||
| + | [[Category: Von Delft F]] | ||
Current revision
Crystal structure of Human Peroxisomal coenzyme A diphosphatase NUDT7
| |||||||||||
Categories: Homo sapiens | Large Structures | Arrowsmith CH | Bountra C | Burgess-Brown N | Edwards AM | Elkins JM | Huber K | Kopec J | Mathea S | Nunez CA | Siejka P | Srikannathasan V | Tallant C | Von Delft F
